Quail Sulf1 Function Requires Asparagine-linked Glycosylation.

Quail Sulf1 Function Requires Asparagine-linked Glycosylation. Research Abstract Details 

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Quail Sulf1 Function Requires Asparagine-linked Glycosylation. Abstract Text:

Rashmi K Ambasta,Xingbin Ai,Charles P Emerson,Rashmi K Ambasta,Xingbin Ai,Charles P Emerson,Rashmi K Ambasta,Xingbin Ai,Charles P Emerson,

The heparan sulfate endosulfatases Sulf1 and Sulf2 are cell-surface enzymes that control growth factor signaling through regulation of the 6-O-sulfation states of cell-surface and matrix heparan sulfate proteoglycans. Here, we report that quail Sulf1 (QSulf1) is an asparagine-linked glycosylated protein. Domain mapping studies in combination with a protein glycosylation prediction program identified multiple asparagine-linked glycosylation sites in the enzymatic and C-terminal domains. Glycosylation inhibitor studies revealed that glycosylation of QSulf1 is essential for its enzymatic activity, membrane targeting, and secretion. Furthermore, N-glycanase cleavage of asparagine-linked sites in native QSulf1 provided direct evidence that these N-linked glycosylation sites are specifically required for QSulf1 heparin binding and its 6-O-desulfation activity, revealing that N-linked glycosylation has a key role in the control of sulfatase enzymatic function.

Quail Sulf1 Function Requires Asparagine-linked Glycosylation. Publishing Authors By Initials

RK Ambasta,X Ai,CP Emerson,RK Ambasta,X Ai,CP Emerson,RK Ambasta,X Ai,CP Emerson,

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Quail Sulf1 Function Requires Asparagine-linked Glycosylation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of biological chemistry

VOLUME: 282

Page Numbers: 34492-9

Journal Abbreviation: J. Biol. Chem.

ISSN: 0021-9258

DAY: 12

MONTH: 09

YEAR: 2007

Quail Sulf1 Function Requires Asparagine-linked Glycosylation. Information

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LANGUAGE: eng

NlmUniqueID: 2985121

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AFFILIATION: Boston Biomedical Research Institute, Watertown, Massachusetts 02472.

Country: United States

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MEDLINETA: J Biol Chem

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