Pyrimidine acyclic nucleoside phosphonates and phosphorylated analogs (part 2): syntheses and investigation of their inhibitory effects towards human thymidine phosphorylase.

Pyrimidine acyclic nucleoside phosphonates and phosphorylated analogs (part 2): syntheses and investigation of their inhibitory effects towards human thymidine phosphorylase. Research Abstract Details 

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Pyrimidine acyclic nucleoside phosphonates and phosphorylated analogs (part 2): syntheses and investigation of their inhibitory effects towards human thymidine phosphorylase. Abstract Text:

Various methods were used in the syntheses of a number of pyrimidine acyclic nucleoside phosphonates and their derivatives such as a nucleophilic fluorination, Suzuki-Miyaura coupling reactions and phosphorylation. These new compounds were further investigated for their potential biological activity. Based on results obtained the ability to inhibit human thymidine phosphorylase some of them was found.

Pyrimidine acyclic nucleoside phosphonates and phosphorylated analogs (part 2): syntheses and investigation of their inhibitory effects towards human thymidine phosphorylase. Publishing Authors By Initials

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Pyrimidine acyclic nucleoside phosphonates and phosphorylated analogs (part 2): syntheses and investigation of their inhibitory effects towards human thymidine phosphorylase. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Nucleic acids symposium series (2004)

VOLUME:

Page Numbers: 657-8

Journal Abbreviation: Nucleic Acids Symp Ser (Oxf)

ISSN: 1746-8272

DAY: 8

MONTH: 09

YEAR: 2008

Pyrimidine acyclic nucleoside phosphonates and phosphorylated analogs (part 2): syntheses and investigation of their inhibitory effects towards human thymidine phosphorylase. Information

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LANGUAGE: eng

NlmUniqueID: 101259965

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AFFILIATION: Gilead Sciences & IOCB Research Centre, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., Centre for New Antivirals and Antineoplastics (IOCB), Flemingovo nám. 2,166 10, Prague, Czech Republic.

Country: England

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MEDLINETA: Nucleic Acids Symp Ser (Oxf)

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