Pyranicin, a non-classical annonaceous acetogenin, is a potent inhibitor of DNA polymerase, topoisomerase and human cancer cell growth.

Pyranicin, a non-classical annonaceous acetogenin, is a potent inhibitor of DNA polymerase, topoisomerase and human cancer cell growth. Research Abstract Details 

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Pyranicin, a non-classical annonaceous acetogenin, is a potent inhibitor of DNA polymerase, topoisomerase and human cancer cell growth. Abstract Text:

Shunya Takahashi,Yuko Yonezawa,Akemi Kubota,Narihito Ogawa,Katsuya Maeda,Hiroyuki Koshino,Tadashi Nakata,Hiromi Yoshida,Yoshiyuki Mizushina,

This report describes the inhibitory activities of the natural and non-natural acetogenins [mucocin (compound 1), jimenezin (compound 2), 19-epi jimenezin (compound 3), muconin (compound 4), pyranicin (compound 5), pyragonicin (compound 6), 10-epi pyragonicin (compound 7), and a gamma-lactone (compound 8)], which were synthesized by us, against DNA polymerase (pol), DNA topoisomerase (topo), and human cancer cell growth. Among the compounds tested, compound 5 was revealed to be the strongest inhibitor of the animal pols and human topos tested, and the IC50 values for pols and topos were 2.3-15.8 and 5.0-7.5 microM, respectively. The compound also suppressed human cancer cell (promyelocytic leukemia cell line, HL-60) growth with the same tendency as the inhibition of pols and topos and the LD50 value was 9.4 microM. Compound 5 arrested the cells at G2/M and G1 phases, and prevented the incorporation of thymidine into the cells, indicating that it blocks DNA replication by inhibiting the activity of pols and topos. This compound also induced apoptosis of the cells. Based on these results, the action mode of compound 5 is discussed.

Pyranicin, a non-classical annonaceous acetogenin, is a potent inhibitor of DNA polymerase, topoisomerase and human cancer cell growth. Publishing Authors By Initials

S Takahashi,Y Yonezawa,A Kubota,N Ogawa,K Maeda,H Koshino,T Nakata,H Yoshida,Y Mizushina,

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Pyranicin, a non-classical annonaceous acetogenin, is a potent inhibitor of DNA polymerase, topoisomerase and human cancer cell growth. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of oncology

VOLUME: 32

Page Numbers: 451-8

Journal Abbreviation: Int. J. Oncol.

ISSN: 1019-6439

DAY: 18

MONTH: Feb

YEAR: 2008

Pyranicin, a non-classical annonaceous acetogenin, is a potent inhibitor of DNA polymerase, topoisomerase and human cancer cell growth. Information

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LANGUAGE: eng

NlmUniqueID: 9306042

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Grant and Affiliation Information for Pyranicin, a non-classical annonaceous acetogenin, is a potent inhibitor of DNA polymerase, topoisomerase and human cancer cell growth.

AFFILIATION: RIKEN (The Institute of Physical and Chemical Research), Wako-shi, Saitama, 351-0198, Japan.

Country: Greece

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MEDLINETA: Int J Oncol

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