Putative association of a TLR9 promoter polymorphism with atopic eczema.

Putative association of a TLR9 promoter polymorphism with atopic eczema. Research Abstract Details 

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Putative association of a TLR9 promoter polymorphism with atopic eczema. Abstract Text:

N Novak,C-F Yu,C Bussmann,L Maintz,W-M Peng,J Hart,T Hagemann,A Diaz-Lacava,H-J Baurecht,N Klopp,S Wagenpfeil,H Behrendt,T Bieber,J Ring,T Illig,S Weidinger,

BACKGROUND: Toll-like receptors (TLR) play a pivotal role in the induction of first-line defense mechanisms of the innate immune system and trigger adaptive immune responses to microbial pathogens. Genetic variations in innate immunity genes have been reported to be associated with a range of inflammatory disorders. Deficiencies on the level of immunity receptors such as pathogen-recognition receptors are suspected to affect the maturation of our immune system and to avail thereby the high prevalence of atopic diseases and susceptibility of atopic patients to microbial infections. AIMS OF THE STUDY: We evaluated TLR9 as susceptibility gene for atopic eczema (AE). METHODS: Analyses of four tag single-nucleotide polymorphisms in two panels of families containing a total of 483 parent-affected offspring trios as well as a cohort of 274 unrelated adult AE cases and 252 hypernormal population-based controls have been performed. RESULTS: In both family cohorts, polymorphism C-1237T, which is located within the promoter region of the TLR9 gene, was significantly associated with AE, in particular the intrinsic subtype of AE. No associations were seen in the case-control cohort. Luciferase reporter gene assays revealed significantly higher promoter activity of the TT allelic variant at this single nucleotide polymorphism site. CONCLUSION: These observations suggest that the TLR9 promoter polymorphism C-1237T might affect AE susceptibility in particular in patients with the intrinsic variant of AE.

Putative association of a TLR9 promoter polymorphism with atopic eczema. Publishing Authors By Initials

N Novak,CF Yu,C Bussmann,L Maintz,WM Peng,J Hart,T Hagemann,A Diaz-Lacava,HJ Baurecht,N Klopp,S Wagenpfeil,H Behrendt,T Bieber,J Ring,T Illig,S Weidinger,

For similar proteins: dna-binding proteins: toll-like receptor 9 research abstracts see: proteins: dna-binding proteins: toll-like receptor 9 research

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Putative association of a TLR9 promoter polymorphism with atopic eczema. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Allergy

VOLUME: 62

Page Numbers: 766-72

Journal Abbreviation: Allergy

ISSN: 0105-4538

DAY: 3

MONTH: Jul

YEAR: 2007

Putative association of a TLR9 promoter polymorphism with atopic eczema. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7804028

Putative association of a TLR9 promoter polymorphism with atopic eczema. Keywords Mesh Terms:

KEYWORDS: Toll-Like Receptor 9

MESH TERMS: genetics

Chemical & Substance for Abstract: Putative association of a TLR9 promoter polymorphism with atopic eczema. Information

Substance Name: Toll-Like Receptor 9

Registry Number: 0

Grant and Affiliation Information for Putative association of a TLR9 promoter polymorphism with atopic eczema.

AFFILIATION: Department of Dermatology, University of Bonn, Bonn, Germany.

Country: Denmark

AGENCY: United States NIAID

GRANT: N01 AI40029

ACRONYM: AI

MEDLINETA: Allergy

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