Purified MHC class I molecules inhibit activated NK cells in a cell-free system in vitro.

Purified MHC class I molecules inhibit activated NK cells in a cell-free system in vitro. Research Abstract Details 

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Purified MHC class I molecules inhibit activated NK cells in a cell-free system in vitro. Abstract Text:

Natural killer cells have been shown to interact with MHC class I molecules via inhibitory receptors. However, it is not known whether the inhibition induced by MHC class I molecules requires other NK cell-target cell interactions. Thus, we examined whether purified MHC class I molecules alone were able to inhibit NK cell function. Purified H-2K(b) and H-2D(b) molecules inhibited the release of IFN-gamma from spleen (H-2(b))-derived lymphokine-activated killer (LAK) cell cultures stimulated by anti-NK1.1 antibody in a concentration-dependent manner. LAK cells generated from newborn mice that express low levels of MHC class I binding Ly49 inhibitory receptors were significantly less sensitive to inhibition by H-2K(b) compared to LAK cells from adult mice. Furthermore, LAK cells generated from spleen cells of Ly49C-transgenic mice were significantly more sensitive to inhibition by H-2K(b) compared to non-transgenic littermates. Taken together, the data indicate that MHC class I induced inhibition of NK cell mediated effector functions, as assessed by IFN-gamma release after NK1.1 triggering, does not require additional cell surface molecules other than MHC class I.

Purified MHC class I molecules inhibit activated NK cells in a cell-free system in vitro. Publishing Authors By Initials

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Purified MHC class I molecules inhibit activated NK cells in a cell-free system in vitro. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: European journal of immunology

VOLUME: 31

Page Numbers: 869-75

Journal Abbreviation: Eur. J. Immunol.

ISSN: 0014-2980

DAY: 26

MONTH: Mar

YEAR: 2001

Purified MHC class I molecules inhibit activated NK cells in a cell-free system in vitro. Information

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LANGUAGE: eng

NlmUniqueID: 1273201

Purified MHC class I molecules inhibit activated NK cells in a cell-free system in vitro. Keywords Mesh Terms:

KEYWORDS: Proteins

MESH TERMS: immunology

Chemical & Substance for Abstract: Purified MHC class I molecules inhibit activated NK cells in a cell-free system in vitro. Information

Substance Name: Ovalbumin

Registry Number: 9006-59-1

Grant and Affiliation Information for Purified MHC class I molecules inhibit activated NK cells in a cell-free system in vitro.

AFFILIATION: Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden.

Country: Germany

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MEDLINETA: Eur J Immunol

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