Purification and properties of beef liver aldehyde reductase catalyzing the reduction of D-erythrose 4-phosphate.

Purification and properties of beef liver aldehyde reductase catalyzing the reduction of D-erythrose 4-phosphate. Research Abstract Details 

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Purification and properties of beef liver aldehyde reductase catalyzing the reduction of D-erythrose 4-phosphate. Abstract Text:

T Terada,T Kohno,T Samejima,S Hosomi,T Mizoguchi,K Uehara,

An aldehyde reductase catalyzing the NADPH-dependent reduction of D-erythrose 4-phosphate to D-erythritol 4-phosphate was purified from beef liver. It was proved to be homogeneous by polyacrylamide gel electrophoresis, sodium dodecyl sulfate polyacrylamide gel electrophoresis and ultracentrifugation analysis. The enzyme was proved to be a monomeric enzyme and its molecular weight was about 40,000. The enzyme was able to reduce not only tetroses but also trioses, aromatic aldehydes, D-glucuronate and succinic semialdehyde. Apparent Km-values for aromatic aldehydes were lower than those for tetroses, trioses, D-glucuronate and succinic semi-aldehyde. Barbiturates and valproate were potent inhibitors of the enzyme and their apparent K1-values were in the range of 80-180 microM. Quercitrin was the most potent inhibitor and its K1-value was about 7 microM. From the viewpoint of substrate specificity and inhibitor sensitivity, it seems that the enzyme belongs to the high-Km type aldehyde reductases.

Purification and properties of beef liver aldehyde reductase catalyzing the reduction of D-erythrose 4-phosphate. Publishing Authors By Initials

T Terada,T Kohno,T Samejima,S Hosomi,T Mizoguchi,K Uehara,

For similar carbohydrates: sugar phosphates research abstracts see: carbohydrates: sugar phosphates research

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Purification and properties of beef liver aldehyde reductase catalyzing the reduction of D-erythrose 4-phosphate. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biochemistry

VOLUME: 97

Page Numbers: 79-87

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Jan

YEAR: 1985

Purification and properties of beef liver aldehyde reductase catalyzing the reduction of D-erythrose 4-phosphate. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Purification and properties of beef liver aldehyde reductase catalyzing the reduction of D-erythrose 4-phosphate. Keywords Mesh Terms:

KEYWORDS: Sugar Phosphates

MESH TERMS: metabolism

Chemical & Substance for Abstract: Purification and properties of beef liver aldehyde reductase catalyzing the reduction of D-erythrose 4-phosphate. Information

Substance Name: alcohol dehydrogenase (NADP+)

Registry Number: EC 1.1.1.2

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Country: JAPAN

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MEDLINETA: J Biochem

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