Pulsed low intensity ultrasound enhances mineralisation in preosteoblast cells.

Pulsed low intensity ultrasound enhances mineralisation in preosteoblast cells. Research Abstract Details 

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Pulsed low intensity ultrasound enhances mineralisation in preosteoblast cells. Abstract Text:

Jenny Unsworth,Saira Kaneez,Sue Harris,Jonathan Ridgway,Steven Fenwick,David Chenery,Andrew Harrison,

Pulsed low intensity ultrasound has been shown to be highly efficacious in the treatment of nonunion fractures and in the acceleration of fresh fracture healing. MC3T3-E1 subclone 14 cells were cultured for up to 25 days either with or without a daily treatment with low intensity pulsed ultrasound. It was determined that, on day 10 there was a dramatic increase in alkaline phosphatase and MMP-13 mRNA levels detected in ultrasound-treated cultures compared with untreated controls. The activity of alkaline phosphatase was significantly increased at days 6, 8 and 10. On day 10, the amount of mineralisation within cultures, assessed using alizarin red staining, was significantly increased in ultrasound-treated cultures compared with untreated controls. These results suggest that one of the mechanisms that low intensity pulsed ultrasound has on fracture repair is to enhance the process of endochondral ossification where the soft callus is converted to mineralised hard callus.

Pulsed low intensity ultrasound enhances mineralisation in preosteoblast cells. Publishing Authors By Initials

J Unsworth,S Kaneez,S Harris,J Ridgway,S Fenwick,D Chenery,A Harrison,

For similar natural sciences: physics: acoustics: ultrasonics research abstracts see: natural sciences: physics: acoustics: ultrasonics research

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Pulsed low intensity ultrasound enhances mineralisation in preosteoblast cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Ultrasound in medicine & biology

VOLUME: 33

Page Numbers: 1468-74

Journal Abbreviation:

ISSN: 0301-5629

DAY: 8

MONTH: 08

YEAR: 2007

Pulsed low intensity ultrasound enhances mineralisation in preosteoblast cells. Information

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LANGUAGE: eng

NlmUniqueID: 410553

Pulsed low intensity ultrasound enhances mineralisation in preosteoblast cells. Keywords Mesh Terms:

KEYWORDS: Ultrasonics

MESH TERMS: methods

Chemical & Substance for Abstract: Pulsed low intensity ultrasound enhances mineralisation in preosteoblast cells. Information

Substance Name: Matrix Metalloproteinase 13

Registry Number: EC 3.4.24.-

Grant and Affiliation Information for Pulsed low intensity ultrasound enhances mineralisation in preosteoblast cells.

AFFILIATION: Smith and Nephew Research Centre, York Science Park, Heslington, York, United Kingdom.

Country: England

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MEDLINETA: Ultrasound Med Biol

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