Pulmonary vascular changes induced by unilateral pulmonary venous obstruction.

Pulmonary vascular changes induced by unilateral pulmonary venous obstruction. Research Abstract Details 

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Pulmonary vascular changes induced by unilateral pulmonary venous obstruction. Abstract Text:

M Endo,S Yamaki,M Hata,Y Saiki,K Tabayashi,

The relation of pulmonary hemodynamics to pathological change in the pulmonary vasculature was examined in a model of unilateral pulmonary venous (PV) obstruction. The left upper pulmonary vein (A group, n=6) or both the left upper and left lower pulmonary veins (B group, n=6) of two-week-old piglets were banded; the control group (n=6) was sham operated. At eight weeks after PV banding, mean pulmonary arterial pressure was highest in the B group, intermediate in the A group and lowest in the control group. In all groups, the media of the pulmonary artery was equally thickened in both lungs, whereas the media of the pulmonary vein was thickened only in those lung lobes having stenotic pulmonary veins. For all animals from three groups, left pulmonary arterial wedge pressure (PAWP) correlated with medial thickness of the pulmonary arteries of the right lung (r=0.76, p=0.003), the left upper lobe (r=0.54, p<0.03), the left lower lobe (r=0.49, p=0.04). This finding suggests that the pathogenesis of PAWP-related medial thickening of the bilateral lung pulmonary artery begins with the sensing by the bilateral lung of PV pressure buildup in the unilateral lung.

Pulmonary vascular changes induced by unilateral pulmonary venous obstruction. Publishing Authors By Initials

M Endo,S Yamaki,M Hata,Y Saiki,K Tabayashi,

For similar circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic phenomena: hemodynamics: vascular resistance research abstracts see: circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic phenomena: hemodynamics: vascular resistance research

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MEDLINE DATE: 2002 Jul-Aug

Pulmonary vascular changes induced by unilateral pulmonary venous obstruction. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pediatric cardiology

VOLUME: 23

Page Numbers: 420-5

Journal Abbreviation: Pediatr Cardiol

ISSN: 0172-0643

DAY: 20

MONTH: 02

YEAR: 2008

Pulmonary vascular changes induced by unilateral pulmonary venous obstruction. Information

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LANGUAGE: eng

NlmUniqueID: 8003849

Pulmonary vascular changes induced by unilateral pulmonary venous obstruction. Keywords Mesh Terms:

KEYWORDS: Vascular Resistance

MESH TERMS: physiology

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Grant and Affiliation Information for Pulmonary vascular changes induced by unilateral pulmonary venous obstruction.

AFFILIATION: Department of Cardiovascular Surgery, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.

Country: United States

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MEDLINETA: Pediatr Cardiol

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