Pulmonary lesions in female harlan sprague-dawley rats following two-year oral treatment with dioxin-like compounds.

Pulmonary lesions in female harlan sprague-dawley rats following two-year oral treatment with dioxin-like compounds. Research Abstract Details 

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Pulmonary lesions in female harlan sprague-dawley rats following two-year oral treatment with dioxin-like compounds. Abstract Text:

Nigel J Walker,Katsuhiko Yoshizawa,Rodney A Miller,Amy E Brix,Donald M Sells,Micheal P Jokinen,Michael E Wyde,Michael Easterling,Abraham Nyska,Nigel J Walker,Katsuhiko Yoshizawa,Rodney A Miller,Amy E Brix,Donald M Sells,Micheal P Jokinen,Michael E Wyde,Michael Easterling,Abraham Nyska,Nigel J Walker,Katsuhiko Yoshizawa,Rodney A Miller,Amy E Brix,Donald M Sells,Micheal P Jokinen,Michael E Wyde,Michael Easterling,Abraham Nyska,

Dioxin and dioxin-related compounds have been associated with high incidences of pulmonary dysfunctions and/or cancers in humans. To evaluate the relative potencies of effects of these compounds, the National Toxicology Program completed a series of two-year bioassays which were conducted using female Harlan Sprague-Dawley rats. The rats were treated orally for up to 2 years with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 3,3',4,4',5-pentachlorobiphenyl (PCB126), 2,3,4,7,8-pentachlorodibenzofuran (PeCDF), and a ternary mixture of TCDD, PCB126 and PeCDF. In addition to treatment-related effects reported in other organs, a variety of pulmonary lesions were observed that were related to exposure. Pulmonary CYP1A1-associated 7-ethoxyresorufin-O-deethylase (EROD) activity was increased in all dosed groups. The most common non-neoplastic lesions, which occurred in all studies, were bronchiolar metaplasia and squamous metaplasia of the alveolar epithelium. Cystic keratinizing epithelioma was the most commonly observed neoplasm which occurred in all studies. A low incidence of squamous cell carcinoma was associated only with PCB126 treatment. Potential mechanisms leading to altered differentiation and/or proliferation of bronchiolar and alveolar epithelia may be through CYP1A1 induction or disruption of retinoid metabolism.

Pulmonary lesions in female harlan sprague-dawley rats following two-year oral treatment with dioxin-like compounds. Publishing Authors By Initials

NJ Walker,K Yoshizawa,RA Miller,AE Brix,DM Sells,MP Jokinen,ME Wyde,M Easterling,A Nyska,NJ Walker,K Yoshizawa,RA Miller,AE Brix,DM Sells,MP Jokinen,ME Wyde,M Easterling,A Nyska,NJ Walker,K Yoshizawa,RA Miller,AE Brix,DM Sells,MP Jokinen,ME Wyde,M Easterling,A Nyska,

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Pulmonary lesions in female harlan sprague-dawley rats following two-year oral treatment with dioxin-like compounds. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Toxicologic pathology

VOLUME: 35

Page Numbers: 880-9

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ISSN: 0192-6233

DAY: 21

MONTH: 12

YEAR: 2007

Pulmonary lesions in female harlan sprague-dawley rats following two-year oral treatment with dioxin-like compounds. Information

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LANGUAGE: eng

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AFFILIATION: National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.

Country: United States

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MEDLINETA: Toxicol Pathol

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