Pulmonary complications of common variable immunodeficiency.

Pulmonary complications of common variable immunodeficiency. Research Abstract Details 

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Pulmonary complications of common variable immunodeficiency. Abstract Text:

Paula J Busse,Sherry Farzan,Charlotte Cunningham-Rundles,

OBJECTIVES: To review pulmonary complications of common variable immunodeficiency (CVID) and summarize data available on the use of replacement antibody treatment to protect against lung changes. DATA SOURCES: Relevant articles regarding CVID and pulmonary disease identified from PubMed and reference lists of review articles. STUDY SELECTION: Key articles were selected by the authors. RESULTS: Patients with CVID often develop acute sinopulmonary infections that can lead to chronic airway inflammation, which can produce substantial morbidity and mortality. Replacement immunoglobulin treatment significantly reduces the reoccurrence of lower airway infections, but the effect on the development of chronic lung damage is not yet clear. Screening examinations, such as pulmonary function testing and high-resolution computed tomography of the chest, can be used to evaluate pulmonary status. Patients with abnormal findings may benefit from more aggressive treatment, including larger doses of immune globulin and the use of prophylactic antibiotics. CONCLUSIONS: Pulmonary complications present a significant comorbidity in CVID; monitoring may indicate which patients require more aggressive treatment.

Pulmonary complications of common variable immunodeficiency. Publishing Authors By Initials

PJ Busse,S Farzan,C Cunningham-Rundles,

For similar respiratory tract diseases: lung diseases research abstracts see: respiratory tract diseases: lung diseases research

PUBMED ID PMID:

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Pulmonary complications of common variable immunodeficiency. Journal Published:

PUBLICATION TYPE: Review

Journal: Annals of allergy, asthma & immunology : official

VOLUME: 98

Page Numbers: 1-8; quiz 8-11, 43

Journal Abbreviation: Ann. Allergy Asthma Immunol.

ISSN: 1081-1206

DAY: 3

MONTH: Jan

YEAR: 2007

Pulmonary complications of common variable immunodeficiency. Information

Number of References: 65

LANGUAGE: eng

NlmUniqueID: 9503580

Pulmonary complications of common variable immunodeficiency. Keywords Mesh Terms:

KEYWORDS: Lung Diseases

MESH TERMS: prevention & control

Chemical & Substance for Abstract: Pulmonary complications of common variable immunodeficiency. Information

Substance Name: Immunoglobulins, Intravenous

Registry Number: 0

Grant and Affiliation Information for Pulmonary complications of common variable immunodeficiency.

AFFILIATION: Allergy and Immunology, Mt Sinai Hospital, New York, New York 10029, USA.

Country: United States

AGENCY: United States NIAID

GRANT: R18 AI48693-04

ACRONYM: AI

MEDLINETA: Ann Allergy Asthma Immunol

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