PTEN modulates GDNF/RET mediated chemotaxis and branching morphogenesis in the developing kidney.

PTEN modulates GDNF/RET mediated chemotaxis and branching morphogenesis in the developing kidney. Research Abstract Details 

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PTEN modulates GDNF/RET mediated chemotaxis and branching morphogenesis in the developing kidney. Abstract Text:

Doyeob Kim,Gregory R Dressler,Doyeob Kim,Gregory R Dressler,

The RET receptor tyrosine kinase is activated by GDNF and controls outgrowth and invasion of the ureteric bud epithelia in the developing kidney. In renal epithelial cells and in enteric neuronal precursor cells, activation of RET results in chemotaxis as Ret expressing cells invade the surrounding GDNF expressing tissue. One potential downstream signaling pathway governing RET mediated chemotaxis may require phosphatidylinositol 3-kinase (PI3K), which generates PI(3,4,5) triphosphate. The PTEN tumor suppressor gene encodes a protein and lipid phosphatase that regulates cell growth, apoptosis and many other cellular processes. PTEN helps regulate cellular chemotaxis by antagonizing the PI3K signaling pathway through dephosphorylation of phosphotidylinositol triphosphates. In this report, we show that PTEN suppresses RET mediated cell migration and chemotaxis in cell culture assays, that RET activation results in asymmetric localization of inositol triphosphates and that loss of PTEN affects the pattern of branching morphogenesis in developing mouse kidneys. These data suggest a critical role for the PI3K/PTEN axis in shaping the pattern of epithelial branches in response to RET activation.

PTEN modulates GDNF/RET mediated chemotaxis and branching morphogenesis in the developing kidney. Publishing Authors By Initials

D Kim,GR Dressler,D Kim,GR Dressler,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

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PTEN modulates GDNF/RET mediated chemotaxis and branching morphogenesis in the developing kidney. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Developmental biology

VOLUME: 307

Page Numbers: 290-9

Journal Abbreviation: Dev. Biol.

ISSN: 0012-1606

DAY: 8

MONTH: 05

YEAR: 2007

PTEN modulates GDNF/RET mediated chemotaxis and branching morphogenesis in the developing kidney. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372762

PTEN modulates GDNF/RET mediated chemotaxis and branching morphogenesis in the developing kidney. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: metabolism

Chemical & Substance for Abstract: PTEN modulates GDNF/RET mediated chemotaxis and branching morphogenesis in the developing kidney. Information

Substance Name: PTEN Phosphohydrolase

Registry Number: EC 3.1.3.67

Grant and Affiliation Information for PTEN modulates GDNF/RET mediated chemotaxis and branching morphogenesis in the developing kidney.

AFFILIATION: Department of Pathology, University of Michigan, MSRB1, BSRB 2049, 109 Zina Pitcher Dr., Ann Arbor, MI 48109, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: DK062914

ACRONYM: DK

MEDLINETA: Dev Biol

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