PTEN gene mutation and high MIB-1 labeling index may contribute to dissemination in patients with glioblastoma.

PTEN gene mutation and high MIB-1 labeling index may contribute to dissemination in patients with glioblastoma. Research Abstract Details 

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PTEN gene mutation and high MIB-1 labeling index may contribute to dissemination in patients with glioblastoma. Abstract Text:

Hideaki Kato,Miki Fujimura,Toshihiro Kumabe,Chikashi Ishioka,Ryunosuke Kanamaru,Takashi Yoshimoto,Hideaki Kato,Miki Fujimura,Toshihiro Kumabe,Chikashi Ishioka,Ryunosuke Kanamaru,Takashi Yoshimoto,

Dissemination of glioblastomas is often observed, but the underlying mechanism is not well clarified especially from the genetic viewpoints. The present study examined whether PTEN gene mutations and MIB-1 labeling index (LI) correlate with the dissemination in 39 consecutive patients with glioblastomas. Dissemination was defined as leptomenigeal enhancement by magnetic resonance imaging performed in all patients every 2-3 months. We examined PTEN mutations in 26 patients using cDNA-based direct sequencing and MIB-1 LI in 38 patients. Median survival time of the 39 patients was 16.2 months. Dissemination was found in 17 of 39 patients (43.6%). PTEN mutation was significantly associated with dissemination (P=0.0140), and higher MIB-1 LI (> or =35%) resulted in earlier dissemination (P=0.0156). Kaplan-Meier survival plots showed a significantly poorer survival for patients with PTEN mutation (P=0.0012). The results indicate that the evaluation of PTEN mutation and MIB-1 LI are useful to predict dissemination and prognosis of glioblastomas.

PTEN gene mutation and high MIB-1 labeling index may contribute to dissemination in patients with glioblastoma. Publishing Authors By Initials

H Kato,M Fujimura,T Kumabe,C Ishioka,R Kanamaru,T Yoshimoto,H Kato,M Fujimura,T Kumabe,C Ishioka,R Kanamaru,T Yoshimoto,

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PTEN gene mutation and high MIB-1 labeling index may contribute to dissemination in patients with glioblastoma. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of clinical neuroscience : official journa

VOLUME: 11

Page Numbers: 37-41

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ISSN: 0967-5868

DAY: 3

MONTH: Jan

YEAR: 2004

PTEN gene mutation and high MIB-1 labeling index may contribute to dissemination in patients with glioblastoma. Information

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LANGUAGE: eng

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Grant and Affiliation Information for PTEN gene mutation and high MIB-1 labeling index may contribute to dissemination in patients with glioblastoma.

AFFILIATION: Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan.

Country: Scotland

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MEDLINETA: J Clin Neurosci

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