PTEN enhances TNF-induced apoptosis through modulation of nuclear factor-kappaB signaling pathway in human glioma cells.

PTEN enhances TNF-induced apoptosis through modulation of nuclear factor-kappaB signaling pathway in human glioma cells. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

PTEN enhances TNF-induced apoptosis through modulation of nuclear factor-kappaB signaling pathway in human glioma cells. Abstract Text:

Dimpy Koul,Yasunari Takada,Ruijun Shen,Bharat B Aggarwal,W K Alfred Yung,

The PTEN tumor suppressor gene modulates cell growth and survival known to be regulated by the activation of the transcription factor NFkappaB, suggesting PTEN might affect the NFkappaB activation pathway. We found that PTEN inhibited NFkappaB activation induced by TNF. The suppression of NFkappaB activation correlated with sequential inhibition of the tumor necrosis factor-induced expression of NFkappaB-regulated anti-apoptotic (IAP1, IAP2, Bcl-2, Bcl-xL, cFLIP, Bfl-1/A1, and survivin) gene products. Downregulation of the antiapoptotic genes by PTEN increased TNF-induced apoptosis, as indicated by caspase activation, TUNEL, annexin staining, and esterase assay. We conclude that the ectopic expression of PTEN enhances TNF-induced apoptosis and downregulates the proliferation of glioma cells through the suppression of various molecules including NFkappaB, and various mediators of cellular survival and proliferation, and that this targets might be essential for its central role in the growth and survival of glioma cancer cells.

PTEN enhances TNF-induced apoptosis through modulation of nuclear factor-kappaB signaling pathway in human glioma cells. Publishing Authors By Initials

D Koul,Y Takada,R Shen,BB Aggarwal,WK Yung,

For similar peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research

PUBMED ID PMID:

MEDLINE DATE:

PTEN enhances TNF-induced apoptosis through modulation of nuclear factor-kappaB signaling pathway in human glioma cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biochemical and biophysical research communication

VOLUME: 350

Page Numbers: 463-71

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 0006-291X

DAY: 25

MONTH: 09

YEAR: 2006

PTEN enhances TNF-induced apoptosis through modulation of nuclear factor-kappaB signaling pathway in human glioma cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372516

PTEN enhances TNF-induced apoptosis through modulation of nuclear factor-kappaB signaling pathway in human glioma cells. Keywords Mesh Terms:

KEYWORDS: Tumor Necrosis Factor-alpha

MESH TERMS: pharmacology

Chemical & Substance for Abstract: PTEN enhances TNF-induced apoptosis through modulation of nuclear factor-kappaB signaling pathway in human glioma cells. Information

Substance Name: PTEN Phosphohydrolase

Registry Number: EC 3.1.3.67

Grant and Affiliation Information for PTEN enhances TNF-induced apoptosis through modulation of nuclear factor-kappaB signaling pathway in human glioma cells.

AFFILIATION: Brain Tumor Center, Department of Neuro-Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. Dkoul@mdanderson.org

Country: United States

AGENCY: United States NCI

GRANT: R01 CA-056041

ACRONYM: CA

MEDLINETA: Biochem Biophys Res Commun

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

PTEN enhances TNF-induced apoptosis through modulation of nuclear factor-kappaB signaling pathway in human glioma cells Related Publications

• 5-HT excites globus pallidus neurons by multiple receptor mechanisms.
• A North American brain tumor consortium (NABTC 99-04) phase II trial of temozolomide plus thalidomide for recurrent glioblastoma multiforme.
• A case of cutaneous symplastic leiomyoma - a rare variant of cutaneous pilar leiomyoma.
• A reciprocal relationship between Rb and Skp2: implications for restriction point control, signal transduction to the cell cycle and cancer.
• An erythematous nodule on the eyelid.
• Association of nucleophosmin/B23 with bladder cancer recurrence based on immunohistochemical assessment in clinical samples.
• Avoidance of BIPP allergy hypersensitivity reactions following ear surgery.
• Can probability of genetic mutation be an indicator of clinical relevance?
• Carrying Neuro-Oncology to a World that Needs Knowledge.
• Cell cycle-dependent nuclear export of phosphatase and tensin homologue tumor suppressor is regulated by the phosphoinositide-3-kinase signaling cascade.
• Diffraction characteristics of photoresist surface-relief gratings.
• Early intervention in psychotic disorders: detection and treatment of the first episode and the critical early stages.
• Effect of aging on bone marrow-derived murine CD11c+CD4-CD8alpha- dendritic cell function.
• Effects of the GABA-uptake inhibitor tiagabine in rat globus pallidus.
• Enhanced production of human interferon-gamma by the use of a combination of inducers--phytohemagglutinin, picibanil and tumor promoting agent.
• Impact of co-occurring substance use on 6 month outcomes for young people seeking mental health treatment.
• Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo.
• Lane detection by orientation and length discrimination.
• Medium term follow-up of a randomized controlled trial of interventions for young people at ultra high risk of psychosis.
• Modulation of synaptic GABA(A) receptor function by zolpidem in substantia nigra pars reticulata.
• New drugs and new delivery techniques.
• PTEN down regulates AP-1 and targets c-fos in human glioma cells via PI3-kinase/Akt pathway.
• PTEN enhances TNF-induced apoptosis through modulation of nuclear factor-kappaB signaling pathway in human glioma cells.
• Potential use of cholecalciferol polyethylene glycol succinate as a novel pharmaceutical additive.
• Pseudochromhidrosis: Blue discolouration of the head and neck.
• Selectivity of folate conjugated polymer micelles against different tumor cells.
• Studying the effects of new peritoneal dialysis solutions on the peritoneum.
• Surgery for esophageal cancer: do age or incorrect data analysis have any impact on clinical outcome?
• Titanium prosthesis with malleus notch: a study of its 'user-friendliness'.
• Well-defined nanoassemblies using gold nanoparticles bearing specific number of DNA strands.