PTEN: a promising pharmacological target to enhance epithelial wound healing.

PTEN: a promising pharmacological target to enhance epithelial wound healing. Research Abstract Details 

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PTEN: a promising pharmacological target to enhance epithelial wound healing. Abstract Text:

M Zhao,M Zhao,M Zhao,

PI3Ks (phosphoinositide-3 kinases) produce PIP3 (phosphatidylinositol(3,4,5)-trisphosphate) which mediates signals for cell survival and proliferation. The tumour suppressor PTEN (phosphatase and tensin homologue) dephosphorylates PIP3 and is a key negative regulator of PI3K signalling. Recent research highlighted important roles for PI3K/PTEN in cell polarization and directional cell migration, pointing to a significant role for PTEN in wound healing where spatially organized tissue growth is essential. Lai et al. (in this issue of British Journal of Pharmacology) have moved a step closer in utilizing PTEN for wound healing through pharmacological inhibition. Two vanadium derivative inhibitors targeting PTEN significantly elevated the level of phosphorylated Akt (protein kinase B) and nearly doubled the wound healing rate in monolayer cultures of lung and airway epithelial cells. Damage to airway and lung epithelia underlies a wide spectrum of significant clinical conditions. With further experiments, this promising approach may find potential clinical use in situations where enhanced wound healing of pulmonary and other epithelia is important.British Journal of Pharmacology (2007) 152, 1141-1144; doi:10.1038/sj.bjp.0707503; published online 8 October 2007.

PTEN: a promising pharmacological target to enhance epithelial wound healing. Publishing Authors By Initials

M Zhao,M Zhao,M Zhao,

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PTEN: a promising pharmacological target to enhance epithelial wound healing. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: British journal of pharmacology

VOLUME: 152

Page Numbers: 1141-4

Journal Abbreviation: Br. J. Pharmacol.

ISSN: 0007-1188

DAY: 8

MONTH: 10

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: [1] 1School of Medical Sciences and Department of Ophthalmology, University of Aberdeen, Aberdeen, Scotland, UK [2] 2Department of Dermatology, School of Medicine, University of California, Davis, CA, USA.

Country: England

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MEDLINETA: Br J Pharmacol

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