[Psychoneuroendocrinology of posttraumatic stress disorder]

[Psychoneuroendocrinology of posttraumatic stress disorder] Research Abstract Details 

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[Psychoneuroendocrinology of posttraumatic stress disorder] Abstract Text:

Juliana Elena Ruiz,Jair Barbosa Neto,Aline Ferri Schoedl,Marcelo Feijo Mello,

OBJECTIVE: To review the literature on neurobiological findings related to hypothalamic-pituitary-adrenal axis dysfunctions associated with posttraumatic stress disorder. METHOD: The relevant scientific findings were described according to the date of publication and the characteristics of the studies: preclinical studies, studies on early life violence as a risk factor, and clinical findings related to patients diagnosed with posttraumatic stress disorder. RESULTS: A rich literature on hypothalamic-pituitary-adrenal axis dysfunctions and posttraumatic stress disorder was found. Neurobiological findings showed that posttraumatic stress disorder is associated with hypothalamic-pituitary-adrenal axis dysfunctions and other brain-related structures: prefrontal cortex, hippocampus, and amygdala. Posttraumatic stress disorder patients have low plasma levels of cortisol and present increased responsivity of glucocorticoid receptors, suggesting that the inhibition of negative feedback plays a significant role in the disorder pathology. Preclinical studies using animal models of maternal deprivation showed that depending on the moment the trauma occurred during the development, different hypothalamic-pituitary-adrenal axis dysfunctions were produced. Clinical studies showed that early life stress is related to the development of psychopathologies during adulthood. CONCLUSIONS: There is robust evidence of hypothalamic-pituitary-adrenal axis dysfunctions related to posttraumatic stress disorder, and the mechanisms underlying this association are being better understood.

[Psychoneuroendocrinology of posttraumatic stress disorder] Publishing Authors By Initials

JE Ruiz,J Barbosa Neto,AF Schoedl,MF Mello,

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[Psychoneuroendocrinology of posttraumatic stress disorder] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Revista brasileira de psiquiatria (São Paulo, Braz

VOLUME: 29 Suppl 1

Page Numbers: S7-12

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ISSN: 1516-4446

DAY: 6

MONTH: May

YEAR: 2007

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LANGUAGE: por

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AFFILIATION: Departamento de Psiquiatria, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Country: Brazil

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MEDLINETA: Rev Bras Psiquiatr

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