Psychological stress compromises CD8+ T cell control of latent herpes simplex virus type 1 infections.

Psychological stress compromises CD8+ T cell control of latent herpes simplex virus type 1 infections. Research Abstract Details 

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Psychological stress compromises CD8+ T cell control of latent herpes simplex virus type 1 infections. Abstract Text:

Michael L Freeman,Brian S Sheridan,Robert H Bonneau,Robert L Hendricks,

Recurrent HSV-1 ocular disease results from reactivation of latent virus in trigeminal ganglia, often following immunosuppression or exposure to a variety of psychological or physical stressors. HSV-specific CD8+ T cells can block HSV-1 reactivation from latency in ex vivo trigeminal ganglia cultures through production of IFN-gamma. In this study, we establish that either CD8+ T cell depletion or exposure to restraint stress permit HSV-1 to transiently escape from latency in vivo. Restraint stress caused a reduction of TG-resident HSV-specific CD8+ T cells and a functional compromise of those cells that survive. Together, these effects of stress resulted in an approximate 65% reduction of cells capable of producing IFN-gamma in response to reactivating virus. Our findings demonstrate persistent in vivo regulation of latent HSV-1 by CD8+ T cells, and strongly support the concept that stress induces HSV-1 reactivation from latency at least in part by compromising CD8+ T cell surveillance of latently infected neurons.

Psychological stress compromises CD8+ T cell control of latent herpes simplex virus type 1 infections. Publishing Authors By Initials

ML Freeman,BS Sheridan,RH Bonneau,RL Hendricks,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology: virus latency research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology: virus latency research

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Psychological stress compromises CD8+ T cell control of latent herpes simplex virus type 1 infections. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 179

Page Numbers: 322-8

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 1

MONTH: Jul

YEAR: 2007

Psychological stress compromises CD8+ T cell control of latent herpes simplex virus type 1 infections. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985117

Psychological stress compromises CD8+ T cell control of latent herpes simplex virus type 1 infections. Keywords Mesh Terms:

KEYWORDS: Virus Latency

MESH TERMS: immunology

Chemical & Substance for Abstract: Psychological stress compromises CD8+ T cell control of latent herpes simplex virus type 1 infections. Information

Substance Name: Interferon Type II

Registry Number: 82115-62-6

Grant and Affiliation Information for Psychological stress compromises CD8+ T cell control of latent herpes simplex virus type 1 infections.

AFFILIATION: Graduate Program in Molecular Virology and Microbiology, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

Country: United States

AGENCY: United States NIAID

GRANT: T32 AI 060525

ACRONYM: AI

MEDLINETA: J Immunol

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