Pseudorotaxane-Like Supramolecular Complex of Coenzyme Q10 with gamma-Cyclodextrin Formed by Solubility Method.

Pseudorotaxane-Like Supramolecular Complex of Coenzyme Q10 with gamma-Cyclodextrin Formed by Solubility Method. Research Abstract Details 

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Pseudorotaxane-Like Supramolecular Complex of Coenzyme Q10 with gamma-Cyclodextrin Formed by Solubility Method. Abstract Text:

The purpose of this study is to reveal whether Coenzyme Q10 (CoQ10) forms pseudorotaxane-like supramolecular complex with gamma-cyclodextrin (gamma-CyD). The poorly soluble complex of CoQ10 with gamma-CyD in water was prepared by the solubility method. The X-ray diffraction pattern of the CoQ10/gamma-CyD complex was different from that of the physical mixture, but almost the same as that of polypropylene glycol (PPG)/gamma-CyD polypseudorotaxane. Also, the differential scanning calorimetrical study and FT-IR study demonstrated the interaction between CoQ10 and gamma-CyD in the solid state. The (1)H-NMR study and the yield study of the supramolecular complex of CoQ10 with gamma-CyD demonstrated that the stoichiometry was 5 : 1 (gamma-CyD : CoQ10). The dispersion rate of CoQ10 was markedly increased by the formation of the supramolecular complex with gamma-CyD, possibly due to submicron-ordered particle formulation. In fact, CoQ10 was found to form submicron-sized supramolecular particles with gamma-CyD, when prepared by the solubility method. Consequently, the present study showed that CoQ10 forms the pseudorotaxane-like supramolecular complex with gamma-CyD in water.

Pseudorotaxane-Like Supramolecular Complex of Coenzyme Q10 with gamma-Cyclodextrin Formed by Solubility Method. Publishing Authors By Initials

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Pseudorotaxane-Like Supramolecular Complex of Coenzyme Q10 with gamma-Cyclodextrin Formed by Solubility Method. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Chemical & pharmaceutical bulletin

VOLUME: 56

Page Numbers: 701-6

Journal Abbreviation: Chem. Pharm. Bull.

ISSN: 0009-2363

DAY: 2

MONTH: May

YEAR: 2008

Pseudorotaxane-Like Supramolecular Complex of Coenzyme Q10 with gamma-Cyclodextrin Formed by Solubility Method. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Pseudorotaxane-Like Supramolecular Complex of Coenzyme Q10 with gamma-Cyclodextrin Formed by Solubility Method.

AFFILIATION: Graduate School of Pharmaceutical Sciences, Kumamoto University.

Country: Japan

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MEDLINETA: Chem Pharm Bull (Tokyo)

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