Proton Spectroscopy in a Cross-Section of HIV-Positive Asymptomatic Patients Receiving Immediate Compared with Deferred Zidovudine (Concorde Study).

Proton Spectroscopy in a Cross-Section of HIV-Positive Asymptomatic Patients Receiving Immediate Compared with Deferred Zidovudine (Concorde Study). Research Abstract Details 

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Proton Spectroscopy in a Cross-Section of HIV-Positive Asymptomatic Patients Receiving Immediate Compared with Deferred Zidovudine (Concorde Study). Abstract Text:

M A Hall-Craggs,I G Williams,I D Wilkinson,M Paley,R J Chinn,W K Chong,B E Kendall,M J Harrison,T Baldeweg,K Pugh,M Riccio,J Catalan,I V Weller,

The purpose of this study was to examine by proton spectroscopy for any difference in cerebral metabolites in patients taking part in the Concorde study (comparing the efficacy of immediate versus deferred treatment with zidovudine on asymptomatic HIV infected individuals). Forty seven HIV positive male patients [29 immediate, 18 deferred zidovudine] were examined in the last 9 months of the therapeutic trial. Magnetic resonance imaging and proton spectroscopy were performed at 1.5 Tesla using a single voxel placed in the parieto-occipital white matter. No significant difference was found in metabolite ratios comparing immediate versus deferred zidovudine (NA/NA+Cho+Cr 0.52 vs. 0.52). High quality spectra were acquired in relatively large numbers of patients and logistically spectroscopy may be applied to clinical therapeutic studies.

Proton Spectroscopy in a Cross-Section of HIV-Positive Asymptomatic Patients Receiving Immediate Compared with Deferred Zidovudine (Concorde Study). Publishing Authors By Initials

MA Hall-Craggs,IG Williams,ID Wilkinson,M Paley,RJ Chinn,WK Chong,BE Kendall,MJ Harrison,T Baldeweg,K Pugh,M Riccio,J Catalan,IV Weller,

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Proton Spectroscopy in a Cross-Section of HIV-Positive Asymptomatic Patients Receiving Immediate Compared with Deferred Zidovudine (Concorde Study). Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of neuro-AIDS

VOLUME: 1

Page Numbers: 103-13

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ISSN: 1069-7438

DAY: 28

MONTH: 07

YEAR: 1997

Proton Spectroscopy in a Cross-Section of HIV-Positive Asymptomatic Patients Receiving Immediate Compared with Deferred Zidovudine (Concorde Study). Information

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LANGUAGE: eng

NlmUniqueID: 9613966

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AFFILIATION: , Mortimer Street, London, W1N 8AA, UK.

Country: United States

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MEDLINETA: J NeuroAIDS

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