Proton MR spectroscopy in mild cognitive impairment and Alzheimer disease: comparison of 1.5 and 3 T.

Proton MR spectroscopy in mild cognitive impairment and Alzheimer disease: comparison of 1.5 and 3 T. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Proton MR spectroscopy in mild cognitive impairment and Alzheimer disease: comparison of 1.5 and 3 T. Abstract Text:

Oded Gonen,

BACKGROUND AND PURPOSE: Theoretically, proton ((1)H) MR spectroscopy at a higher field strength has the advantages of higher signal-to-noise ratio and improved spectral resolution. We therefore compared the ability of single-voxel (1)H MR spectroscopy at 1.5 and 3 T to diagnostically discriminate among cognitively normal elderly subjects, patients with mild cognitive impairment (MCI), and patients with Alzheimer disease (AD). METHODS: At both 1.5 and 3 T, we studied 41 cognitively normal elderly subjects, 20 patients with MCI, and 20 patients with AD. In each subject, (1)H MR spectroscopy was performed at TEs of 30 and 135 ms and from voxels placed over the posterior cingulate gyri. RESULTS: Average line widths and interexamination variability of metabolite ratios were higher at 3 T than at 1.5 T. Consistent quantification of glutamine (Gln) + glutamate/creatine (Cr) and Gln/Cr peak ratios occurred at 3 T but not at 1.5 T. Choline (Cho)/Cr (at TE = 135 ms) and myo-inositol (MI)/Cr were higher and N-acetylaspartate (NAA)/Cr (at TE = 135 ms) and NAA/MI were lower in patients with MCI than in cognitively normal subjects only at 1.5 T. MI/Cr and Cho/Cr were higher and NAA/Cr and NAA/MI were lower in patients with AD than in cognitively normal subjects at both 1.5 and 3 T. Differentiation of patients with AD from cognitively normal subjects by using the NAA/MI data was similar at both field strengths (P >.05). CONCLUSION: With currently available technology, the diagnostic performance of (1)H MR spectroscopy in patients with MCI and those with AD was not better at 3 T than at 1.5 T.

Proton MR spectroscopy in mild cognitive impairment and Alzheimer disease: comparison of 1.5 and 3 T. Publishing Authors By Initials

O Gonen,

For similar roc curve research abstracts see: roc curve research

PUBMED ID PMID:

MEDLINE DATE:

Proton MR spectroscopy in mild cognitive impairment and Alzheimer disease: comparison of 1.5 and 3 T. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: AJNR. American journal of neuroradiology

VOLUME: 24

Page Numbers: 843-9

Journal Abbreviation:

ISSN: 0195-6108

DAY: 14

MONTH: May

YEAR: 2003

Proton MR spectroscopy in mild cognitive impairment and Alzheimer disease: comparison of 1.5 and 3 T. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8003708

Proton MR spectroscopy in mild cognitive impairment and Alzheimer disease: comparison of 1.5 and 3 T. Keywords Mesh Terms:

KEYWORDS: ROC Curve

MESH TERMS: methods

Chemical & Substance for Abstract: Proton MR spectroscopy in mild cognitive impairment and Alzheimer disease: comparison of 1.5 and 3 T. Information

Substance Name: N-acetylaspartate

Registry Number: 997-55-7

Grant and Affiliation Information for Proton MR spectroscopy in mild cognitive impairment and Alzheimer disease: comparison of 1.5 and 3 T.

AFFILIATION: Department of Diagnostic Radiology, Milwaukee, WI, USA.

Country: United States

AGENCY: United States NIA

GRANT: AG16574

ACRONYM: AG

MEDLINETA: AJNR Am J Neuroradiol

REFSOURCE: AJNR Am J Neuroradiol. 2003 May;24(5):78

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Proton MR spectroscopy in mild cognitive impairment and Alzheimer disease: comparison of 15 and 3 T Related Publications

• 3D maps from multiple MRI illustrate changing atrophy patterns as subjects progress from mild cognitive impairment to Alzheimer's disease.
• A critical analysis of local anesthesia as an agent for the relief of pain in vaginal delivery.
• Alzheimer's disease diagnosis in individual subjects using structural MR images: Validation studies.
• Applying comprehensive community-based approaches in diabetes prevention: rationale, principles, and models.
• Assessment of functional MR imaging in neurosurgical planning.
• Balancing Big Pharma's books.
• Bone anomalies of the tarsus in relation to peroneal spastic flat foot.
• Conserved C-terminal motifs of the Arabidopsis proteins APETALA3 and PISTILLATA are dispensable for floral organ identity function.
• Counterfeit medicines. Bitter pills.
• DORNROSCHEN-LIKE, an AP2 gene, is necessary for stamen emergence in Arabidopsis.
• EWEN ALISTAIR JACK, 1909-1953.
• Experimental rupture of the medial collateral ligament of the knee.
• Functional heterogeneity of the supplementary motor area.
• Hippocampal T2 relaxometry in epilepsy: past, present, and future.
• Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease.
• MRI patterns of atrophy associated with progression to AD in amnestic mild cognitive impairment.
• Medial temporal lobe volumetrics in traumatic brain injury.
• Naviculo-cuneiform fusion in the treatment of flat foot.
• Outreach monitoring service for patients with indolent B-cell and plasma cell disorders: a UK experience.
• Patterns of atrophy differ among specific subtypes of mild cognitive impairment.
• Plasma ascorbic acid levels in Nigerian children of Niger delta region of Nigeria.
• Posterior peripheral detachment of the lateral cartilage.
• Proton MR spectroscopy in mild cognitive impairment and Alzheimer disease: comparison of 1.5 and 3 T.
• Relation of triglycerides to phosphoglycerides in fungi.
• Structure and dynamics of glass formers: Predictability at large length scales.
• Understanding rehospitalization risk: can hospital discharge be modified to reduce recurrent hospitalization?
• Use of milk fat fractions in baked products.
• Voxel-based morphometry in autopsy proven PSP and CBD.
• [A nurse sees her professional colleagues at the bedside of her sick mother. Nurses: competent and insensitive]
• ef1097 and ypkK encode enterococcin V583 and corynicin JK, members of a new family of antimicrobial proteins (bacteriocins) with modular structure from Gram-positive bacteria.