Proton magnetic resonance spectroscopy of lenticular nuclei in obsessive-compulsive disorder.

Proton magnetic resonance spectroscopy of lenticular nuclei in obsessive-compulsive disorder. Research Abstract Details 

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Proton magnetic resonance spectroscopy of lenticular nuclei in obsessive-compulsive disorder. Abstract Text:

Magnetic resonance spectroscopy (MRS) is a safe and non-invasive technique for the in vivo study of brain chemistry and metabolism. As such, it is highly applicable to the study of living brain tissue in psychiatric diseases. Several neuropathological and neuroimaging studies have suggested that abnormalities of the basal ganglia nuclei might be implicated in patients with obsessive-compulsive disorder (OCD). In the present study, we performed proton [1H]MRS of the lenticular nuclei in 12 patients with OCD and 12 healthy normal comparison subjects. The peaks of N-acetyl-aspartate (NAA), creatine (Cr), and choline-containing compounds (Cho) were measured. No differences between OCD patients and normal subjects were found in the NAA/Cr, Cho/Cr and NAA/Cho ratios. Our results suggest the normal viability of neuronal cells, as indicated by the quantification of NAA, Cr and Cho in the lenticular nuclei of patients with OCD.

Proton magnetic resonance spectroscopy of lenticular nuclei in obsessive-compulsive disorder. Publishing Authors By Initials

For similar behavioral disciplines and activities: psychiatric status rating scales research abstracts see: behavioral disciplines and activities: psychiatric status rating scales research

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Proton magnetic resonance spectroscopy of lenticular nuclei in obsessive-compulsive disorder. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Psychiatry research

VOLUME: 92

Page Numbers: 83-91

Journal Abbreviation: Psychiatry Res

ISSN: 0165-1781

DAY: 20

MONTH: Dec

YEAR: 1999

Proton magnetic resonance spectroscopy of lenticular nuclei in obsessive-compulsive disorder. Information

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LANGUAGE: eng

NlmUniqueID: 7911385

Proton magnetic resonance spectroscopy of lenticular nuclei in obsessive-compulsive disorder. Keywords Mesh Terms:

KEYWORDS: Psychiatric Status Rating Scales

MESH TERMS: metabolism

Chemical & Substance for Abstract: Proton magnetic resonance spectroscopy of lenticular nuclei in obsessive-compulsive disorder. Information

Substance Name: Choline

Registry Number: 62-49-7

Grant and Affiliation Information for Proton magnetic resonance spectroscopy of lenticular nuclei in obsessive-compulsive disorder.

AFFILIATION: Department of Psychiatry, Hamamatsu University School of Medicine, Shizuoka, Japan.

Country: IRELAND

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MEDLINETA: Psychiatry Res

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