Proton echo-planar spectroscopic imaging of J-coupled resonances in human brain at 3 and 4 Tesla.

Proton echo-planar spectroscopic imaging of J-coupled resonances in human brain at 3 and 4 Tesla. Research Abstract Details 

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Proton echo-planar spectroscopic imaging of J-coupled resonances in human brain at 3 and 4 Tesla. Abstract Text:

Stefan Posse,Ricardo Otazo,Arvind Caprihan,Juan Bustillo,Hongji Chen,Pierre-Gilles Henry,Malgorzata Marjanska,Charles Gasparovic,Chun Zuo,Vincent Magnotta,Bryon Mueller,Paul Mullins,Perry Renshaw,Kamil Ugurbil,Kelvin O Lim,Jeffry R Alger,

In this multicenter study, 2D spatial mapping of J-coupled resonances at 3T and 4T was performed using short-TE (15 ms) proton echo-planar spectroscopic imaging (PEPSI). Water-suppressed (WS) data were acquired in 8.5 min with 1-cm(3) spatial resolution from a supraventricular axial slice. Optimized outer volume suppression (OVS) enabled mapping in close proximity to peripheral scalp regions. Constrained spectral fitting in reference to a non-WS (NWS) scan was performed with LCModel using correction for relaxation attenuation and partial-volume effects. The concentrations of total choline (tCho), creatine + phosphocreatine (Cr+PCr), glutamate (Glu), glutamate + glutamine (Glu+Gln), myo-inositol (Ins), NAA, NAA+NAAG, and two macromolecular resonances at 0.9 and 2.0 ppm were mapped with mean Cramer-Rao lower bounds (CRLBs) between 6% and 18% and approximately 150-cm(3) sensitive volumes. Aspartate, GABA, glutamine (Gln), glutathione (GSH), phosphoethanolamine (PE), and macromolecules (MMs) at 1.2 ppm were also mapped, although with larger mean CRLBs between 30% and 44%. The CRLBs at 4T were 19% lower on average as compared to 3T, consistent with a higher signal-to-noise ratio (SNR) and increased spectral resolution. Metabolite concentrations were in the ranges reported in previous studies. Glu concentration was significantly higher in gray matter (GM) compared to white matter (WM), as anticipated. The short acquisition time makes this methodology suitable for clinical studies.

Proton echo-planar spectroscopic imaging of J-coupled resonances in human brain at 3 and 4 Tesla. Publishing Authors By Initials

S Posse,R Otazo,A Caprihan,J Bustillo,H Chen,PG Henry,M Marjanska,C Gasparovic,C Zuo,V Magnotta,B Mueller,P Mullins,P Renshaw,K Ugurbil,KO Lim,JR Alger,

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Proton echo-planar spectroscopic imaging of J-coupled resonances in human brain at 3 and 4 Tesla. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Magnetic resonance in medicine : official journal

VOLUME: 58

Page Numbers: 236-44

Journal Abbreviation:

ISSN: 0740-3194

DAY: 3

MONTH: Aug

YEAR: 2007

Proton echo-planar spectroscopic imaging of J-coupled resonances in human brain at 3 and 4 Tesla. Information

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LANGUAGE: eng

NlmUniqueID: 8505245

Proton echo-planar spectroscopic imaging of J-coupled resonances in human brain at 3 and 4 Tesla. Keywords Mesh Terms:

KEYWORDS: Signal Processing, Computer-Assisted

MESH TERMS: methods

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Grant and Affiliation Information for Proton echo-planar spectroscopic imaging of J-coupled resonances in human brain at 3 and 4 Tesla.

AFFILIATION: Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA. sposse@unm.edu

Country: United States

AGENCY: United States NCRR

GRANT: P41 RR08079

ACRONYM: RR

MEDLINETA: Magn Reson Med

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