Proton and sodium MRI assessment of emerging tumor chemotherapeutic resistance.

Proton and sodium MRI assessment of emerging tumor chemotherapeutic resistance. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Proton and sodium MRI assessment of emerging tumor chemotherapeutic resistance. Abstract Text:

Victor D Schepkin,Kuei C Lee,Kyle Kuszpit,Mukilan Muthuswami,Timothy D Johnson,Thomas L Chenevert,Alnawaz Rehemtulla,Brian D Ross,

The ultimate goal of any cancer therapy is to target the elimination of neoplastic cells. Although newer therapeutic strategies are in constant development, therapeutic assessment has been hampered by the inability to assess, rapidly and quantitatively, efficacy in vivo. Diffusion imaging and, more recently, sodium MRI have demonstrated their distinct abilities to detect therapy-induced alterations in tumor cellularity, which has been demonstrated to be indicative of therapeutic efficacy. More importantly, both imaging modalities detect tumor response much earlier than traditional methodologies that rely on macroscopic volumetric changes. In this study, the correlation between tumor sodium and diffusion was further tested to demonstrate the sensitivity of sodium imaging to gauge tumor response to therapy by using a 9L rat gliosarcoma treated with varying doses of BCNU [1,3-bis(2-chloroethyl)-1-nitrosourea]. This orthotopic model has been demonstrated to display variability in response to BCNU therapy where initial insult has been shown to lead to drug-resistance. In brief, a single 26.6 mg/kg BCNU dose yielded dramatic responses in both diffusion and sodium MRI. However, a second equivalent BCNU dose yielded a much smaller change in diffusion and sodium, suggesting a drop in tumor sensitivity to BCNU. The MRI responses of animals treated with 13.3 mg/kg BCNU were much lower and similar responses were observed after the initial and secondary applications of BCNU. Furthermore, these results were further validated using volumetric measurements of the tumor and also ex vivo determination of tumor sensitivity to BCNU. Overall, these experiments demonstrate the sensitivity and applicability of sodium and diffusion MRI as tools for dynamic assessment of tumor response to therapy.

Proton and sodium MRI assessment of emerging tumor chemotherapeutic resistance. Publishing Authors By Initials

VD Schepkin,KC Lee,K Kuszpit,M Muthuswami,TD Johnson,TL Chenevert,A Rehemtulla,BD Ross,

For similar inorganic chemicals: elements: metals, alkali: sodium research abstracts see: inorganic chemicals: elements: metals, alkali: sodium research

PUBMED ID PMID:

MEDLINE DATE:

Proton and sodium MRI assessment of emerging tumor chemotherapeutic resistance. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: NMR in biomedicine

VOLUME: 19

Page Numbers: 1035-42

Journal Abbreviation:

ISSN: 0952-3480

DAY: 3

MONTH: Dec

YEAR: 2006

Proton and sodium MRI assessment of emerging tumor chemotherapeutic resistance. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8915233

Proton and sodium MRI assessment of emerging tumor chemotherapeutic resistance. Keywords Mesh Terms:

KEYWORDS: Sodium

MESH TERMS: methods

Chemical & Substance for Abstract: Proton and sodium MRI assessment of emerging tumor chemotherapeutic resistance. Information

Substance Name: Sodium

Registry Number: 7440-23-5

Grant and Affiliation Information for Proton and sodium MRI assessment of emerging tumor chemotherapeutic resistance.

AFFILIATION: National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL 32310, USA.

Country: England

AGENCY: United States NCI

GRANT: R24CA83099

ACRONYM: CA

MEDLINETA: NMR Biomed

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Proton and sodium MRI assessment of emerging tumor chemotherapeutic resistance Related Publications

• A minimum CR2 binding domain of C3d enhances immunity following vaccination.
• Attitudes of genetic counselors towards expanding newborn screening and offering predictive genetic testing to children.
• Benjamin M. Baker, JR.: 1901-2003.
• Birth characteristics, maternal reproductive history, and the risk of infant leukemia: a report from the Children's Oncology Group.
• Carnitine as a possible adjunct in parenteral feeding.
• Chronic vitamin A status and acute repletion with retinyl palmitate are determinants of the distribution and catabolism of all-trans-retinoic acid in rats.
• Circadian rhythms play role in cancer research.
• Complement inactivating proteins and intraspecies venom variation in Crotalus oreganus helleri.
• Differences in cyclin D2 and D1 protein expression distinguish forebrain progenitor subsets.
• Diffusion imaging: insight to cell status and cytoarchitecture.
• Failure of embryos from bluetongue infected cattle to transmit virus to susceptible recipients or their offspring.
• Gestational programming of offspring obesity/hypertension.
• Kinetics of glial glutamine efflux and the mechanism of neuronal uptake studied in vivo in mildly hyperammonemic rat brain.
• Language use in females with fragile X or Turner syndrome during brief initial social interactions.
• Lentivirus-like particles without reverse transcriptase elicit efficient immune responses.
• Maternal hemoglobin concentration during pregnancy and risk of infant leukaemia: a children's oncology group study.
• More to the E-Ferol case than presented.
• Neurologic Manifestations
  of HIV Infection Without AIDS:Follow-UP of a Cohort
  of Homosexual and Bisexual Men.
• Penicillin; applied pharmacology.
• Phosphorylation-regulated inhibition of the Gz GTPase-activating protein activity of RGS proteins by synapsin I.
• Prospective early response imaging biomarker for neoadjuvant breast cancer chemotherapy.
• Proton and sodium MRI assessment of emerging tumor chemotherapeutic resistance.
• Random activation energy model and disordered kinetics, from static to dynamic disorder.
• Reduction of anti-HIV-1 Gag immune responses during co-immunization: immune interference by the HIV-1 envelope.
• Species differences in the in vitro metabolism of deltamethrin and esfenvalerate: differential oxidative and hydrolytic metabolism by humans and rats.
• The effect of lactation length on the circulating concentrations of progesterone and oestradiol in the early weaned sow.
• Transoral surgery: an anatomic study.
• Use of modified pericranial flaps in anterior skull base reconstruction: technical note.
• Vascular targeted nanoparticles for imaging and treatment of brain tumors.
• Virus-like particles: designing an effective AIDS vaccine.