Proteomics of canine lymphoma identifies potential cancer-specific protein markers.

Proteomics of canine lymphoma identifies potential cancer-specific protein markers. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Proteomics of canine lymphoma identifies potential cancer-specific protein markers. Abstract Text:

Dudley L McCaw,Arvan S Chan,Andrew L Stegner,Brian Mooney,Jeffrey N Bryan,Susan E Turnquist,Carolyn J Henry,Hannah Alexander,Stephen Alexander,

PURPOSE: Early diagnosis of cancer is crucial for the success of treatment of the disease, and there is a need for markers whose differential expression between disease and normal tissue could be used as a diagnostic tool. Spontaneously occurring malignancies in pets provide a logical tool for translational research for human oncology. Lymphoma, one of the most common neoplasms in dogs, is similar to human non-Hodgkin's lymphoma and could serve as an experimental model system. EXPERIMENTAL DESIGN: Thirteen lymph nodes from normal dogs and 11 lymph nodes from dogs with B-cell lymphoma were subjected to proteomic analysis using two-dimensional PAGE separation and matrix-assisted laser desorption/ionization time-of-flight analysis. RESULTS: A total of 93 differentially expressed spots was subjected to matrix-assisted laser desorption/ionization time-of-flight tandem mass spectrometry analysis, and several proteins that showed differential expression were identified. Of these, prolidase (proline dipeptidase), triosephosphate isomerase, and glutathione S-transferase were down-regulated in lymphoma samples, whereas macrophage capping protein was up-regulated in the lymphoma samples. CONCLUSIONS: These proteins represent potential markers for the diagnosis of lymphoma and should be further investigated in human samples for validation of their utility as diagnostic markers.

Proteomics of canine lymphoma identifies potential cancer-specific protein markers. Publishing Authors By Initials

DL McCaw,AS Chan,AL Stegner,B Mooney,JN Bryan,SE Turnquist,CJ Henry,H Alexander,S Alexander,

For similar biological factors: biological markers: tumor markers, biological research abstracts see: biological factors: biological markers: tumor markers, biological research

PUBMED ID PMID:

MEDLINE DATE:

Proteomics of canine lymphoma identifies potential cancer-specific protein markers. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Clinical cancer research : an official journal of

VOLUME: 13

Page Numbers: 2496-503

Journal Abbreviation:

ISSN: 1078-0432

DAY: 15

MONTH: Apr

YEAR: 2007

Proteomics of canine lymphoma identifies potential cancer-specific protein markers. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9502500

Proteomics of canine lymphoma identifies potential cancer-specific protein markers. Keywords Mesh Terms:

KEYWORDS: Tumor Markers, Biological

MESH TERMS: analysis

Chemical & Substance for Abstract: Proteomics of canine lymphoma identifies potential cancer-specific protein markers. Information

Substance Name: Tumor Markers, Biological

Registry Number: 0

Grant and Affiliation Information for Proteomics of canine lymphoma identifies potential cancer-specific protein markers.

AFFILIATION: Department of Veterinary Medicine and Surgery, University of Missouri, Columbia, Missouri 65211, USA. McCawD@missouri.edu

Country: United States

AGENCY: United States NIGMS

GRANT: GM53929

ACRONYM: GM

MEDLINETA: Clin Cancer Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Proteomics of canine lymphoma identifies potential cancer-specific protein markers Related Publications

• 2006 Curt P. Richter award winner: Social influences on stress responses and health.
• A comparison of patient and physician beliefs about infrainguinal bypass operation: what role should surgical optimism play?
• A kinematic analysis of the rapid step test in balance-impaired and unimpaired older women.
• Activation of innate immunity by prostate specific antigen (PSA).
• Caveolin-dependent angiotensin II type 1 receptor signaling in vascular smooth muscle.
• Commentary.
• Comparison of the Digene Hybrid Capture System Cytomegalovirus (CMV) DNA (version 2.0), Roche CMV UL54 analyte-specific reagent, and QIAGEN RealArt CMV LightCycler PCR reagent tests using AcroMetrix OptiQuant CMV DNA quantification panels and specimens fr
• Drug use patterns in Northern Territory Aboriginal communities 1986-1987.
• Dynamic balance and stepping versus tai chi training to improve balance and stepping in at-risk older adults.
• Editorial.
• Genetic relationships between feral cattle from Chirikof Island, Alaska and other breeds.
• Guest Editorial: Outcomes in spinal cord injury.
• Hybrid diffusion imaging.
• Juvenile syndecan-1 null mice are protected from carcinogen-induced tumor development.
• Maximum step length: relationships to age and knee and hip extensor capacities.
• Orangutans use compliant branches to lower the energetic cost of locomotion.
• Outpatient rehabilitation of patients with chronic cognitive impairments after ruptured anterior communicating artery aneurysms reduces the burden of care: a pilot study.
• Prenatal influences and endothelial dysfunction: a link between reduced placental perfusion and preeclampsia.
• Proteomics of canine lymphoma identifies potential cancer-specific protein markers.
• Racial and ethnic differences in perinatal mortality: the role of fetal death.
• Relationship between the theory of planned behavior, mobility impairment and physical activity in older adults: 1951: board #21 may 31 3:30 PM - 5:00 PM.
• School employees: the forgotten municipal workers.
• Semantic and phonetic enhancements for speech-in-noise recognition by native and non-native listeners.
• Sensitive cell viability assay for use in drug screens and for studying the mechanism of action of drugs in Dictyostelium discoideum.
• Simulating mouse mammary gland development: cell ageing and its relation to stem and progenitor activity.
• Terahertz direct-contact refractometer/spectrometer.
• Testosterone contributes to marked elevations in mean arterial pressure in adult male intrauterine growth restricted offspring.
• The bath environment, the bathing task, and the older adult: a review and future directions for bathing disability research.
• Vitamin E supplementation does not improve survival from infection in mice when given after burn injury.
• Wnt signaling induces differentiation of progenitor cells in organotypic keratinocyte cultures.