Proteomics finding heat shock protein 27 as a biomarker for resistance of pancreatic cancer cells to gemcitabine.

Proteomics finding heat shock protein 27 as a biomarker for resistance of pancreatic cancer cells to gemcitabine. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Proteomics finding heat shock protein 27 as a biomarker for resistance of pancreatic cancer cells to gemcitabine. Abstract Text:

Sayaka Mori-Iwamoto,Yasuhiro Kuramitsu,Shomei Ryozawa,Kuniko Mikuria,Masanori Fujimoto,Shin-Ichiro Maehara,Yoshihiro Maehara,Kiwamu Okita,Kazuyuki Nakamura,Isao Sakaida,Sayaka Mori-Iwamoto,Yasuhiro Kuramitsu,Shomei Ryozawa,Kuniko Mikuria,Masanori Fujimoto,Shin-Ichiro Maehara,Yoshihiro Maehara,Kiwamu Okita,Kazuyuki Nakamura,Isao Sakaida,Sayaka Mori-Iwamoto,Yasuhiro Kuramitsu,Shomei Ryozawa,Kuniko Mikuria,Masanori Fujimoto,Shin-Ichiro Maehara,Yoshihiro Maehara,Kiwamu Okita,Kazuyuki Nakamura,Isao Sakaida,

Pancreatic cancer remains a devastating disease and >96% of patients with pancreatic cancer do not survive for more than 5 years. Gemcitabine (2'-deoxy-2'-difluoro-deoxycytidine: Gemzar) appears to be the only clinically effective drug for pancreatic cancer, but it has little impact on outcome. Proteomic analysis of gemcitabine-sensitive cells (KLM1) and resistant pancreatic cells (KLM1-R) was performed to identify target proteins of the gemcitabine. We found seven proteins, HSP27, peroxiredoxin 2, endoplasmic reticulum protein ERp29 precursor, 6-phosphogluconolactonase, triosphospate isomerase, alpha enolase, and nucleophosmine that could play a role in determining the sensitivity of pancreatic cancer to gemcitabine. We knocked down HSP27 in KLM1-R and the sensitivity to gemcitabine was restored. In addition, increased HSP27 expression in tumor specimens was related to higher resistibility to gemcitabine in patients of pancreatic cancer. HSP27 may play an important role in the resistibility to gemcitabine, and it could also be a possible biomarker for predicting the response of pancreatic cancer patients to treatment with gemcitabine.

Proteomics finding heat shock protein 27 as a biomarker for resistance of pancreatic cancer cells to gemcitabine. Publishing Authors By Initials

S Mori-Iwamoto,Y Kuramitsu,S Ryozawa,K Mikuria,M Fujimoto,S Maehara,Y Maehara,K Okita,K Nakamura,I Sakaida,S Mori-Iwamoto,Y Kuramitsu,S Ryozawa,K Mikuria,M Fujimoto,S Maehara,Y Maehara,K Okita,K Nakamura,I Sakaida,S Mori-Iwamoto,Y Kuramitsu,S Ryozawa,K Mikuria,M Fujimoto,S Maehara,Y Maehara,K Okita,K Nakamura,I Sakaida,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Proteomics finding heat shock protein 27 as a biomarker for resistance of pancreatic cancer cells to gemcitabine. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of oncology

VOLUME: 31

Page Numbers: 1345-50

Journal Abbreviation: Int. J. Oncol.

ISSN: 1019-6439

DAY: 5

MONTH: Dec

YEAR: 2007

Proteomics finding heat shock protein 27 as a biomarker for resistance of pancreatic cancer cells to gemcitabine. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9306042

Proteomics finding heat shock protein 27 as a biomarker for resistance of pancreatic cancer cells to gemcitabine. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Proteomics finding heat shock protein 27 as a biomarker for resistance of pancreatic cancer cells to gemcitabine. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Proteomics finding heat shock protein 27 as a biomarker for resistance of pancreatic cancer cells to gemcitabine.

AFFILIATION: Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.

Country: Greece

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Int J Oncol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Proteomics finding heat shock protein 27 as a biomarker for resistance of pancreatic cancer cells to gemcitabine Related Publications

• A new hepatic encephalopathy model to monitor the change of neural amino acids and astrocytes with behaviour disorder.
• Autologous bone marrow cell infusion therapy for liver cirrhosis.
• Continuous high expression of XBP1 and GRP78 is important for the survival of bone marrow cells in CCl4-treated cirrhotic liver.
• Effect of a late evening snack on outpatients with liver cirrhosis.
• Epstein-Barr virus upregulates phosphorylated heat shock protein 27 kDa in carcinoma cells using the phosphoinositide 3-kinase/Akt pathway.
• Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription.
• Importance of inhibitor of DNA binding/differentiation 2 in hepatic stellate cell differentiation and proliferation.
• Mitochondrial electron transport inhibition in full genomic hepatitis C virus replicon cells is restored by reducing viral replication.
• Pilot study of combination therapy with transcatheter arterial infusion chemotherapy using iodized oil and percutaneous radiofrequency ablation during occlusion of hepatic blood flow for hepatocellular carcinoma.
• Prospective randomized study on the use of a computer-based endoscopic simulator for training in esophagogastroduodenoscopy.
• Proteomics finding heat shock protein 27 as a biomarker for resistance of pancreatic cancer cells to gemcitabine.
• Screening of hepatocellular cancer: Japanese strategy.
• Serum S100b (astrocyte-specific protein) is a useful marker of hepatic encephalopathy in patients with fulminant hepatitis.
• Study on the colonoscopic features of GVHD enteritis that developed after hematopoietic stem cell transplantation.
• Telmisartan prevents hepatic fibrosis and enzyme-altered lesions in liver cirrhosis rat induced by a choline-deficient L-amino acid-defined diet.
• The effect of supplementation with branched-chain amino acids in patients with liver cirrhosis.
• The long-term efficacy of Helicobacter pylori eradication therapy in patients with idiopathic thrombocytopenic purpura.
• Ulceration after arterial microcoil embolization.
• Ulcerous change decreases the accuracy of endoscopic ultrasonography diagnosis for the invasive depth of early gastric cancer.