Proteomic signatures in laryngeal squamous cell carcinoma.

Proteomic signatures in laryngeal squamous cell carcinoma. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Proteomic signatures in laryngeal squamous cell carcinoma. Abstract Text:

Duane A Sewell,Chao-Xing Yuan,Erle Robertson,

Laryngeal cancer remains a worldwide health problem. The identification of biomarkers unique to laryngeal cancer may provide new insights into its pathogenesis, as well as provide potential targets for novel therapies and early detection. In order to identify potential biomarkers, we performed a proteomic analysis of laryngeal cancer specimens. Using two-dimensional differential in-gel electrophoresis and mass spectroscopy, protein expression profiles from two laryngeal carcinoma specimens and corresponding adjacent normal tissue were analyzed. The results of our analysis showed that the expression of a number of proteins was significantly altered in the tumor specimens when compared to matched normal controls. The differentially expressed proteins were identified, and they included stratifin, S100 calcium-binding protein A9, p21-ARC, stathmin, and enolase. With these findings, we have identified potential biomarkers which may contribute to the pathogenesis of laryngeal carcinoma, and which may be suitable as targets for novel therapeutic and/or diagnostic modalities.

Proteomic signatures in laryngeal squamous cell carcinoma. Publishing Authors By Initials

DA Sewell,CX Yuan,E Robertson,

For similar biological factors: biological markers: tumor markers, biological research abstracts see: biological factors: biological markers: tumor markers, biological research

PUBMED ID PMID:

MEDLINE DATE:

Proteomic signatures in laryngeal squamous cell carcinoma. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: ORL; journal for oto-rhino-laryngology and its rel

VOLUME: 69

Page Numbers: 77-84

Journal Abbreviation: ORL J. Otorhinolaryngol. Relat

ISSN: 0301-1569

DAY: 24

MONTH: 11

YEAR: 2006

Proteomic signatures in laryngeal squamous cell carcinoma. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 334721

Proteomic signatures in laryngeal squamous cell carcinoma. Keywords Mesh Terms:

KEYWORDS: Tumor Markers, Biological

MESH TERMS: genetics

Chemical & Substance for Abstract: Proteomic signatures in laryngeal squamous cell carcinoma. Information

Substance Name: SFN protein, human

Registry Number: EC 3.1.-

Grant and Affiliation Information for Proteomic signatures in laryngeal squamous cell carcinoma.

AFFILIATION: Department of Otorhinolaryngology, Tumor Virology Program of the Abramson Comprehensive Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. dsewell@mail.med.upenn.edu

Country: Switzerland

AGENCY: United States NIDCR

GRANT: DE14136-01

ACRONYM: DE

MEDLINETA: ORL J Otorhinolaryngol Relat S

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Proteomic signatures in laryngeal squamous cell carcinoma Related Publications

• 614.
• A randomized, double-blind, crossover trial of modafinil on mood.
• Attenuating illusory binding with TMS of the right parietal cortex.
• Biotransformation of Cannabidiol to Cannabielsoin by Suspension Cultures of Cannabis sativa and Saccharum officinarum.
• Effect of dose and time of injection of prostaglandin F(2alpha) in cycling ewes.
• Heteromeric assembly of human ether-à-go-go-related gene (hERG) 1a/1b channels occurs cotranslationally via N-terminal interactions.
• Inducing motor skill improvements with a declarative task.
• International symposium on enhancing the effectiveness of alcohol ignition interlock programs.
• Laparoscopy for intrauterine insemination and embryo recovery in superovulated ewes at a commercial embryo transfer unit.
• Management of intracranial hypertension.
• Motor sequence consolidation: constrained by critical time windows or competing components.
• Neurologic and neurodevelopmental manifestations of pediatric HIV/AIDS: a global perspective.
• Ns10 anterior approaches for thoracolumbar fractures.
• Optimal sustained attention is linked to the spectral content of background EEG activity: greater ongoing tonic alpha (approximately 10 Hz) power supports successful phasic goal activation.
• Oxidative stress and impaired insulin secretion in type 2 diabetes.
• Pharmacologic inhibition of epigenetic modifications, coupled with gene expression profiling, reveals novel targets of aberrant DNA methylation and histone deacetylation in lung cancer.
• Pharmacology of N-, L-, and B-subtypes of nematode nAChR resolved at the single-channel level in Ascaris suum.
• Physiologic and histologic determinants of gas exchange during induction of oleic acid pulmonary edema.
• Proteomic signatures in laryngeal squamous cell carcinoma.
• Repetitive transcranial magnetic stimulation for Tourette syndrome.
• Reversal of defective glucagon responses to hypoglycemia in insulin-dependent autoimmune diabetic BB rats.
• Targeting mitogen-activated protein kinase/extracellular signal-regulated kinase kinase in the mutant (V600E) B-Raf signaling cascade effectively inhibits melanoma lung metastases.
• The effect of two different levels of progesterone priming on the response of ewes to superovulation.
• The minimal replicator element of the Kaposi's sarcoma-associated herpesvirus terminal repeat supports replication in a semiconservative and cell-cycle-dependent manner.
• Too many trees to see the forest: performance, event-related potential, and functional magnetic resonance imaging manifestations of integrative congenital prosopagnosia.
• Unusual features of the cell cycle in mycobacteria: polar-restricted growth and the snapping-model of cell division.
• Validation Of Session RPE For A Load Incremented Estimation Cycle Ergometer Protocol: 615: May 30 3:15 PM 3:30 PM.
• Validation of the Adult OMNI Pain Scale During Cycling Exercise: 618: May 30 4:00 PM 4:15 PM.
• Word Memory Test failure 23 times higher in mild brain injury than in parents seeking custody: the power of external incentives.
• Zinc, not insulin, regulates the rat alpha-cell response to hypoglycemia in vivo.