Proteomic analysis of stage I primary lung adenocarcinoma aimed at individualisation of postoperative therapy.

Proteomic analysis of stage I primary lung adenocarcinoma aimed at individualisation of postoperative therapy. Research Abstract Details 

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Proteomic analysis of stage I primary lung adenocarcinoma aimed at individualisation of postoperative therapy. Abstract Text:

J Maeda,T Hirano,A Ogiwara,S Akimoto,T Kawakami,Y Fukui,T Oka,Y Gong,R Guo,H Inada,K Nawa,M Kojika,Y Suga,T Ohira,K Mukai,H Kato,J Maeda,T Hirano,A Ogiwara,S Akimoto,T Kawakami,Y Fukui,T Oka,Y Gong,R Guo,H Inada,K Nawa,M Kojika,Y Suga,T Ohira,K Mukai,H Kato,

Although postoperative adjuvant chemotherapy (PAC) with uracil-tegafur significantly improves the prognosis of patients with stage I lung adenocarcinoma, subset analysis has revealed that only 11.5% of patients with stage IB derive actual benefit from such therapy. Therefore, it is extremely important to identify patients for whom adjuvant chemotherapy will be beneficial. We performed comprehensive protein analysis of 24 surgically resected specimens of stage I adenocarcinoma using liquid chromatography-tandem mass spectrometry (LC-MS/MS), followed by bioinformatical investigations to identify protein molecules. Furthermore, we carried out immunohistochemical studies of 90 adenocarcinoma specimens to validate the results of LC-MS/MS. We detected two kinds of protein molecules (myosin IIA and vimentin) by LC-MS/MS. We confirmed their immunohistochemical expression and distribution, and evaluated the relationship between the expression of these proteins and prognosis after adjuvant chemotherapy. Patients with no expression of either myosin IIA or vimentin showed a significantly better outcome regardless of PAC using uracil-tegafur. However, we were unable to select responders to uracil-tegafur using these proteins. Cases of adenocarcinoma lacking expression of either myosin IIA or vimentin show a good outcome without PAC, and therefore do not require such treatment.British Journal of Cancer (2008) 98, 596-603. doi:10.1038/sj.bjc.6604197 www.bjcancer.com Published online 22 January 2008.

Proteomic analysis of stage I primary lung adenocarcinoma aimed at individualisation of postoperative therapy. Publishing Authors By Initials

J Maeda,T Hirano,A Ogiwara,S Akimoto,T Kawakami,Y Fukui,T Oka,Y Gong,R Guo,H Inada,K Nawa,M Kojika,Y Suga,T Ohira,K Mukai,H Kato,J Maeda,T Hirano,A Ogiwara,S Akimoto,T Kawakami,Y Fukui,T Oka,Y Gong,R Guo,H Inada,K Nawa,M Kojika,Y Suga,T Ohira,K Mukai,H Kato,

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Proteomic analysis of stage I primary lung adenocarcinoma aimed at individualisation of postoperative therapy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: British journal of cancer

VOLUME: 98

Page Numbers: 596-603

Journal Abbreviation: Br. J. Cancer

ISSN: 0007-0920

DAY: 22

MONTH: 01

YEAR: 2008

Proteomic analysis of stage I primary lung adenocarcinoma aimed at individualisation of postoperative therapy. Information

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LANGUAGE: eng

NlmUniqueID: 370635

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AFFILIATION: 1Department of Surgery, Tokyo Medical University, 6-7-1 Nishi-shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.

Country: England

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MEDLINETA: Br J Cancer

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