Proteolytic regulatory mechanisms in the formation of extracellular morphogen gradients.

Proteolytic regulatory mechanisms in the formation of extracellular morphogen gradients. Research Abstract Details 

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Proteolytic regulatory mechanisms in the formation of extracellular morphogen gradients. Abstract Text:

Ellen K LeMosy,

Growth factors are secreted into the extracellular space, where they encounter soluble inhibitors, extracellular matrix glycoproteins and proteoglycans, and proteolytic enzymes that can each modulate the spatial distribution, activity state, and receptor interactions of these signaling molecules. During development, morphogenetic gradients of these growth factors pattern fields of cells responsive to different levels of signaling, creating such structures as the branched pattern of airways and vasculature, and the arrangement of digits in the hand. This review focuses specifically on the roles of proteolytic enzymes and their regulators in the generation of such activity gradients. Evidence from Drosophila developmental pathways provides a detailed understanding of general mechanisms underlying proteolytic control of morphogen gradients, while recent studies of several mammalian growth factors illustrate the relevance of this proteolytic control to human development and disease.

Proteolytic regulatory mechanisms in the formation of extracellular morphogen gradients. Publishing Authors By Initials

EK LeMosy,

For similar carbohydrates: polysaccharides: proteoglycans research abstracts see: carbohydrates: polysaccharides: proteoglycans research

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Proteolytic regulatory mechanisms in the formation of extracellular morphogen gradients. Journal Published:

PUBLICATION TYPE: Review

Journal: Birth defects research. Part C, Embryo today : rev

VOLUME: 78

Page Numbers: 243-55

Journal Abbreviation: Birth Defects Res. C Embryo To

ISSN: 1542-975X

DAY: 3

MONTH: Sep

YEAR: 2006

Proteolytic regulatory mechanisms in the formation of extracellular morphogen gradients. Information

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LANGUAGE: eng

NlmUniqueID: 101167665

Proteolytic regulatory mechanisms in the formation of extracellular morphogen gradients. Keywords Mesh Terms:

KEYWORDS: Proteoglycans

MESH TERMS: physiology

Chemical & Substance for Abstract: Proteolytic regulatory mechanisms in the formation of extracellular morphogen gradients. Information

Substance Name: Proteoglycans

Registry Number: 0

Grant and Affiliation Information for Proteolytic regulatory mechanisms in the formation of extracellular morphogen gradients.

AFFILIATION: Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, Georgia 30912, USA. elemosy@mcg.edu

Country: United States

AGENCY: United States NIGMS

GRANT: GM67738

ACRONYM: GM

MEDLINETA: Birth Defects Res C Embryo Tod

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