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- Induction and maintenance of new bone formation by growth and differentiation factors. The cell biology of bone formation can be better understood by dissecting the complex multistep process into individual steps. It is well known that...

- Induction of bone in composites of osteogenin and porous hydroxyapatite in baboons. A major goal of the combined effort of basic scientists and plastic and reconstructive surgeons is the development of novel bone substitutes based on...

- Inhibition of human serum cholinesterase by some 4-hydroxy-coumarin derivatives.

- Initiation of bone development by osteogenin and promotion by growth factors. The cellular and molecular basis of bone development and its regulation by differentiation and growth factors is an exciting area of current research. This...

- Instability at chromosomal fragile sites. Chromosomal fragile sites are loci that are especially prone to forming gaps or breaks on metaphase chromosomes when cells are cultured under conditions that...

- Interaction between adenosine triphosphate and potassium chloride-soluble proteins of sea urchin eggs.

- Interaction of osteogenin, a heparin binding bone morphogenetic protein, with type IV collagen. Osteogenin, an extracellular matrix component of bone, is a heparin binding differentiation factor that initiates endochondral bone formation in rats when...

- Intermolecular cross-linking of a novel rice Kinesin k16 motor domain with a photoreactive ATP derivative. A fluorescent photoreactive ATP derivative, 2'(3')-O-(4-benzoylbenzoyl)-1,N(6)-etheno-ATP (Bz(2)-epsilonATP), was synthesized and reacted with the rice...

- Interpreting correlated motions using normal mode analysis. With the increased popularity of normal mode analyses in structural biology, it is important to carefully consider how to best utilize the results for...

- Intracellular degradation of histidine-rich glycoprotein mutants: tokushima-1 and 2 mutants are degraded by different proteolytic systems. We reported the first case of a congenital histidine-rich glycoprotein deficiency (HRG Tokushima) in which substitution of Gly85 with Glu (G85E) in the first...

- Intracellular transport of pancreatic enzymes. Most pancreatic secretory proteins are packaged within the trans-Golgi network into zymogen granules, which are secreted in a regulated manner by exocytosis....

- Isolation and biological activities of limulus anticoagulant (anti-LPS factor) which interacts with lipopolysaccharide (LPS). Exposure of limulus hemocytes to bacterial endotoxins (lipopolysaccharide, LPS) results in the activation of the intracellular clotting system, consisting of...

- Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma. By use of its affinity to gelatin-Cellulofine, a novel protein, GBP28 (gelatin-binding protein of 28 kDa), was obtained from human plasma. GBP28 bound to...

- Isolation and characterization of Physarum profilin. A protein that functionally resembles mammalian and Acanthamoeba profilins, has been purified from Physarum plasmodia. Physarum profilin consists of a single...

- Isolation and purification of a low-molecular-weight skeletal growth factor from human bones. A low-molecular-weight potent bone cell mitogen termed human skeletal growth factor (human SGF) was purified to homogeneity from human bone matrix....

- Isolation from cochlea of a novel human intronless gene with predominant fetal expression. We have cloned a novel human gene, designated PFET1 (predominantly fetal expressed T1 domain) (HUGO-approved symbol KCTD12 or C13orf2), by subtractive...

- Isolation of chloroquine-resistant Chinese hamster V79 cell variants that are also resistant to ammonium chloride. Chloroquine-resistant (CQr) clones (CQ-21 and CQ-22) have been isolated from mutagenized hamster lung V79 cells by exposing the cells to a high dose of...

- Isolation of murine hepatic lymphocytes using mechanical dissection for phenotypic and functional analysis of NK1.1+ cells. AIM: To choose an appropriate methods for the isolation of hepatic lymphocytes between the mechanical dissection and the enzymatic digestion and investigate...

- Liver-specific growth factors. Experimental evidence of the existence of liver-specific growth factors has been collected for more than two decades. Blood-borne growth-promoting activity...

- Local bone growth factors.