Tetanus Toxin

- A means for targeting therapeutics to peripheral nervous system neurons with axonal damage. OBJECTIVE: Delivery of biological therapeutics to motor and dorsal root ganglion neurons remains a major hurdle in the development of treatments for a...

- Effect of tetanus toxin on presynaptic inhibition in the spinal cord.

- Electrospray mass spectrometry of NeuAc oligomers associated with the C fragment of the tetanus toxin. The Clostridial neurotoxins, botulinum and tetanus, gain entry into motor neurons by binding to the sialic or N-acetylneuraminic acid (NeuAc) residues of...

- Expression and characterisation of the heavy chain of tetanus toxin: reconstitution of the fully-recombinant dichain protein in active form. Tetanus toxin, composed of a disulphide-linked heavy (HC) and light (LC) chain, preferentially blocks the release of inhibitory neurotransmitters in the...

- Growth of clostridium tetani in vivo.

- Increased expression of GAD mRNA during the chronic epileptic syndrome due to intrahippocampal tetanus toxin. A few mouse minimum lethal doses (MLD) of tetanus toxin injected into rat hippocampus triggers prolonged changes in neuronal function. Spontaneously...

- Motor neuron targeting of IGF-1 attenuates age-related external Ca2+-dependent skeletal muscle contraction in senescent mice. A population of fast muscle fibers from aging mice is dependent on external Ca(2+) to maintain tetanic force during repeated contractions. We hypothesized...

- On-chip native gel electrophoresis-based immunoassays for tetanus antibody and toxin. By integrating photopolymerized cross-linked polyacrylamide gels within a microfluidic device, we have developed a microanalytical platform for performing...

- Present data on the pathogenesis of tetanus.

- Reduced aspartate release from rat hippocampal synaptosomes loaded with Clostridial toxin light chain by electroporation: evidence for an exocytotic mechanism. Aspartate can be released from certain hippocampal pathways along with glutamate or GABA. Although aspartate immunoreactivity has been localized to synaptic...

- Relations between the effect of tetanus toxin on the neuromuscular transmission and histological functional properties of various muscles of the rat.

- Tetanus toxin induced actions on spinal Renshaw cells and Ia-inhibitory interneurones during development of local tetanus in the cat. In anaesthetized cats the activities of Renshaw cells (RCs) and Ia-inhibitory interneurones (IaINs) were recorded during the accumulation of tetanus toxin in...

- The chemical component of the mixed GF-TTMn synapse in Drosophila melanogaster uses acetylcholine as its neurotransmitter. The largest central synapse in adult Drosophila is a mixed electro-chemical synapse whose gap junctions require the product of the shaking-B (shak-B) gene....

- [Antigen localization at the ultrastructural level in Clostridium tetani]

- [Studies on the amino acids transformation of the liquid 10-days-old culture of Clostridium tetani. VI. Comparative quantitative determination of the free amino acid media and filtrates of the 10-day-old culture of Clostridium tetani]

- [Ultrastructural visualization of binding and internalization of cholera and tetanuts toxins] In monolayer cultures of a liver line, a population of non-coated membrane microinvaginations is preferentially involved in both the initial binding and...