Protein translocation by bacterial toxin channels: a comparison of diphtheria toxin and colicin Ia.

Protein translocation by bacterial toxin channels: a comparison of diphtheria toxin and colicin Ia. Research Abstract Details 

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Protein translocation by bacterial toxin channels: a comparison of diphtheria toxin and colicin Ia. Abstract Text:

Zhengyan Wu,Karen S Jakes,Ben S Samelson-Jones,Bing Lai,Gang Zhao,Erwin London,Alan Finkelstein,

Regions of both colicin Ia and diphtheria toxin N-terminal to the channel-forming domains can be translocated across planar phospholipid bilayer membranes. In this article we show that the translocation pathway of diphtheria toxin allows much larger molecules to be translocated than does the translocation pathway of colicin Ia. In particular, the folded A chain of diphtheria toxin is readily translocated by that toxin but is not translocated by colicin Ia. This difference cannot be attributed to specific recognition of the A chain by diphtheria toxin's translocation pathway because the translocation pathway also accommodates folded myoglobin.

Protein translocation by bacterial toxin channels: a comparison of diphtheria toxin and colicin Ia. Publishing Authors By Initials

Z Wu,KS Jakes,BS Samelson-Jones,B Lai,G Zhao,E London,A Finkelstein,

For similar biochemical phenomena, metabolism, and nutrition: metabolism: biological transport: protein transport research abstracts see: biochemical phenomena, metabolism, and nutrition: metabolism: biological transport: protein transport research

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Protein translocation by bacterial toxin channels: a comparison of diphtheria toxin and colicin Ia. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biophysical journal

VOLUME: 91

Page Numbers: 3249-56

Journal Abbreviation: Biophys. J.

ISSN: 0006-3495

DAY: 11

MONTH: 08

YEAR: 2006

Protein translocation by bacterial toxin channels: a comparison of diphtheria toxin and colicin Ia. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370626

Protein translocation by bacterial toxin channels: a comparison of diphtheria toxin and colicin Ia. Keywords Mesh Terms:

KEYWORDS: Protein Transport

MESH TERMS: chemistry

Chemical & Substance for Abstract: Protein translocation by bacterial toxin channels: a comparison of diphtheria toxin and colicin Ia. Information

Substance Name: Phospholipids

Registry Number: 0

Grant and Affiliation Information for Protein translocation by bacterial toxin channels: a comparison of diphtheria toxin and colicin Ia.

AFFILIATION: Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM08572

ACRONYM: GM

MEDLINETA: Biophys J

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