Protein structure and oligomerization are important for the formation of export-competent HIV-1 Rev-RRE complexes.

Protein structure and oligomerization are important for the formation of export-competent HIV-1 Rev-RRE complexes. Research Abstract Details 

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Protein structure and oligomerization are important for the formation of export-competent HIV-1 Rev-RRE complexes. Abstract Text:

Stephen P Edgcomb,Angelique Aschrafi,Elizabeth Kompfner,James R Williamson,Larry Gerace,Mirko Hennig,Stephen P Edgcomb,Angelique Aschrafi,Elizabeth Kompfner,James R Williamson,Larry Gerace,Mirko Hennig,

The translation of the unspliced and partially spliced viral mRNAs that encode the late, structural proteins of HIV-1 depends on the viral-protein Rev. Oligomeric binding of Rev to the Rev response element (RRE) in these mRNAs promotes their export from the nucleus and thus controls their expression. Here, we compared the effects of hydrophobic to hydrophilic mutations within the oligomerization domain of Rev using assays for oligomeric RNA binding, protein structure, and export from the nucleus. Oligomeric RNA binding alone does not correlate well with RNA transport activity in the subset of mutants. However, protein structure as judged by CD spectroscopy does correlate well with Rev function. The oligomeric assembly of Rev-L18T is impaired but exhibits minor defects in structure and retains a basal level of activity in vivo. The prevalence of L18T in infected individuals suggests a positive selection mechanism for L18T modulation of Rev activity that may delay the onset of AIDS.

Protein structure and oligomerization are important for the formation of export-competent HIV-1 Rev-RRE complexes. Publishing Authors By Initials

SP Edgcomb,A Aschrafi,E Kompfner,JR Williamson,L Gerace,M Hennig,SP Edgcomb,A Aschrafi,E Kompfner,JR Williamson,L Gerace,M Hennig,

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Protein structure and oligomerization are important for the formation of export-competent HIV-1 Rev-RRE complexes. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Protein science : a publication of the Protein Soc

VOLUME: 17

Page Numbers: 420-30

Journal Abbreviation: Protein Sci.

ISSN: 0961-8368

DAY: 24

MONTH: 01

YEAR: 2008

Protein structure and oligomerization are important for the formation of export-competent HIV-1 Rev-RRE complexes. Information

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LANGUAGE: eng

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MEDLINETA: Protein Sci

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