Protein S is essential for the activated protein C-catalyzed inactivation of platelet-associated factor Va.

Protein S is essential for the activated protein C-catalyzed inactivation of platelet-associated factor Va. Research Abstract Details 

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Protein S is essential for the activated protein C-catalyzed inactivation of platelet-associated factor Va. Abstract Text:

K Suzuki,J Nishioka,M Matsuda,H Murayama,S Hashimoto,

The prothrombin-converting activity of Factor Xa was enhanced by thrombin-stimulated Factor V-deficient platelets and supplementary extraneous Factor Va, and also by thrombin-stimulated normal human platelets. Both extraneous Factor Va and intra-platelet Factor Va were equally inactivated by a gamma-carboxyglutamic acid-containing plasma protease, activated protein C. However, a relatively larger amount of activated protein C was required for efficient inactivation of platelet-associated Factor Va as compared with the amount of activated protein C needed for inactivation of phospholipid vesicle-associated Factor Va. Protein S, another gamma-carboxyglutamic acid-containing plasma protein, increased the rate of the inactivation of platelet-associated Factor Va about 25-fold. This stimulating effect was observed only slightly with the thrombin-modified protein S. Thus, it was concluded that protein S is essential for the process of inactivation of platelet-associated Factor Va by activated protein C.

Protein S is essential for the activated protein C-catalyzed inactivation of platelet-associated factor Va. Publishing Authors By Initials

K Suzuki,J Nishioka,M Matsuda,H Murayama,S Hashimoto,

For similar enzymes and coenzymes: enzymes: hydrolases: peptide hydrolases: endopeptidases: serine endopeptidases: thrombin research abstracts see: enzymes and coenzymes: enzymes: hydrolases: peptide hydrolases: endopeptidases: serine endopeptidases: thrombin research

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Protein S is essential for the activated protein C-catalyzed inactivation of platelet-associated factor Va. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 96

Page Numbers: 455-60

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Aug

YEAR: 1984

Protein S is essential for the activated protein C-catalyzed inactivation of platelet-associated factor Va. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Protein S is essential for the activated protein C-catalyzed inactivation of platelet-associated factor Va. Keywords Mesh Terms:

KEYWORDS: Thrombin

MESH TERMS: physiology

Chemical & Substance for Abstract: Protein S is essential for the activated protein C-catalyzed inactivation of platelet-associated factor Va. Information

Substance Name: Factor Xa

Registry Number: EC 3.4.21.6

Grant and Affiliation Information for Protein S is essential for the activated protein C-catalyzed inactivation of platelet-associated factor Va.

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Country: JAPAN

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MEDLINETA: J Biochem

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