Protein quality control: the who's who, the where's and therapeutic escapes.

Protein quality control: the who's who, the where's and therapeutic escapes. Research Abstract Details 

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Protein quality control: the who's who, the where's and therapeutic escapes. Abstract Text:

Jürgen Roth,Gary Hin-Fai Yam,Jingyu Fan,Kiyoko Hirano,Katarina Gaplovska-Kysela,Valerie Le Fourn,Bruno Guhl,Roger Santimaria,Tania Torossi,Martin Ziak,Christian Zuber,

In cells the quality of newly synthesized proteins is monitored in regard to proper folding and correct assembly in the early secretory pathway, the cytosol and the nucleoplasm. Proteins recognized as non-native in the ER will be removed and degraded by a process termed ERAD. ERAD of aberrant proteins is accompanied by various changes of cellular organelles and results in protein folding diseases. This review focuses on how the immunocytochemical labeling and electron microscopic analyses have helped to disclose the in situ subcellular distribution pattern of some of the key machinery proteins of the cellular protein quality control, the organelle changes due to the presence of misfolded proteins, and the efficiency of synthetic chaperones to rescue disease-causing trafficking defects of aberrant proteins.

Protein quality control: the who's who, the where's and therapeutic escapes. Publishing Authors By Initials

J Roth,GH Yam,J Fan,K Hirano,K Gaplovska-Kysela,V Le Fourn,B Guhl,R Santimaria,T Torossi,M Ziak,C Zuber,

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Protein quality control: the who's who, the where's and therapeutic escapes. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Histochemistry and cell biology

VOLUME: 129

Page Numbers: 163-77

Journal Abbreviation: Histochem. Cell Biol.

ISSN: 0948-6143

DAY: 13

MONTH: 12

YEAR: 2007

Protein quality control: the who's who, the where's and therapeutic escapes. Information

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LANGUAGE: eng

NlmUniqueID: 9506663

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Grant and Affiliation Information for Protein quality control: the who's who, the where's and therapeutic escapes.

AFFILIATION: Division of Cell and Molecular Pathology, Department of Pathology, University of Zurich, 8091, Zurich, Switzerland, jurgen.roth@bluewin.ch.

Country: Germany

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MEDLINETA: Histochem Cell Biol

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