Protein phosphorylation and the nuclear organization of pre-mRNA splicing.

Protein phosphorylation and the nuclear organization of pre-mRNA splicing. Research Abstract Details 

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Protein phosphorylation and the nuclear organization of pre-mRNA splicing. Abstract Text:

T Misteli,D L Spector,

Controlled execution of transcription and pre-mRNA splicing is crucial for proper gene expression. The organization of these essential events within the cell nucleus is only beginning to be understood. Here, we describe a model for the cellular arrangement of transcription and pre-mRNA splicing based on recent biochemical and morphological data: transcription and pre-mRNA splicing are spatially and temporally coordinated, and protein phosphorylation regulates both the activity and the subnuclear localization of pre-mRNA splicing factors in nuclear subcompartments.

Protein phosphorylation and the nuclear organization of pre-mRNA splicing. Publishing Authors By Initials

T Misteli,DL Spector,

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Protein phosphorylation and the nuclear organization of pre-mRNA splicing. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Trends in cell biology

VOLUME: 7

Page Numbers: 135-8

Journal Abbreviation: Trends Cell Biol.

ISSN: 0962-8924

DAY: 21

MONTH: Apr

YEAR: 1997

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LANGUAGE: eng

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Country: England

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MEDLINETA: Trends Cell Biol

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