Protein levels of heme oxygenase-1 during reperfusion in human kidney transplants with delayed graft function.

Protein levels of heme oxygenase-1 during reperfusion in human kidney transplants with delayed graft function. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Protein levels of heme oxygenase-1 during reperfusion in human kidney transplants with delayed graft function. Abstract Text:

Introduction: Delayed graft function (DGF) as a consequence of ischemia reperfusion injury (IRI) is associated with a decrease in long-term allograft survival. Heme oxygenase-1 (HO-1) is a stress responsive gene that is highly expressed in multiple pathological processes. The aim of our study was to analyze whether HO-1 protein levels in human kidney transplants during IRI correlate with the incidence of DGF. Methods: Kidney biopsies were obtained from 27 kidney allografts at two time points: at the end of cold storage and shortly after reperfusion. Samples were analyzed for HO-1 protein levels by Western blot. Results: Heme oxygenase-1 protein levels were significantly higher in post-reperfusion biopsies (39.4 vs. 13.7 arbitrary units, p = 0.001). In pre-reperfusion biopsies no association was observed between HO-1 protein levels and DGF. In post-reperfusion biopsies, higher levels of HO-1 protein were measured in kidneys with DGF (53.7 vs. 36.2 arbitrary units, p = 0.064). DGF kidneys showed a significantly higher increase from pre- to post-reperfusion in HO-1 protein (42.0 vs. 18.7 arbitrary units, p = 0.025). Conclusion: Heme oxygenase-1 protein levels shortly after allograft reperfusion are closely related with initial graft function. Assessment thereof may be considered a valuable tool to predict DGF.

Protein levels of heme oxygenase-1 during reperfusion in human kidney transplants with delayed graft function. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE: 2008 Jul-Aug

Protein levels of heme oxygenase-1 during reperfusion in human kidney transplants with delayed graft function. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical transplantation

VOLUME: 22

Page Numbers: 418-23

Journal Abbreviation:

ISSN: 1399-0012

DAY: 3

MONTH: 02

YEAR: 2008

Protein levels of heme oxygenase-1 during reperfusion in human kidney transplants with delayed graft function. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8710240

Protein levels of heme oxygenase-1 during reperfusion in human kidney transplants with delayed graft function. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Protein levels of heme oxygenase-1 during reperfusion in human kidney transplants with delayed graft function. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Protein levels of heme oxygenase-1 during reperfusion in human kidney transplants with delayed graft function.

AFFILIATION: Department of General and Transplant Surgery, D. Swarovski Research Lab, Medical University Innsbruck, Innsbruck, Austria.

Country: Denmark

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Clin Transplant

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Protein levels of heme oxygenase-1 during reperfusion in human kidney transplants with delayed graft function Related Publications

• Bilirubin Inhibits Tumor Cell Growth via Activation of ERK.
• Cortical motor activation patterns following hand transplantation and replantation.
• Hepatic artery reconstruction with inferior mesenteric vein graft in pediatric living donor liver transplantation.
• Impact of smoking on progression of vascular diseases and patient survival in type-1 diabetic patients after simultaneous kidney-pancreas transplantation in a single centre.
• Organ transplantation and obesity: evaluation, risks and benefits of therapeutic strategies.
• Protein levels of heme oxygenase-1 during reperfusion in human kidney transplants with delayed graft function.
• Proteinuria disappears promptly after simultaneous kidney-pancreas transplantation in nephrotic diabetic patients with near-normal GFR.
• The 'Blind Innsbruck Ostomy', a cutaneous enterostomy for long-term histologic surveillance after small bowel transplantation.
• [A new method of orthotopic liver transplantation from the guinea pig to the rat]
• [Development and importance of combined organ transplantation]
• [Extensive plasma exchange in treatment of acute vascular graft rejection of the kidney and pancreas]
• [Immediate measures and clinical treatment of local hypothermia]
• [Indications and results of liver transplantation]