Protein kinase C-epsilon protects MCF-7 cells from TNF-mediated cell death by inhibiting Bax translocation.

Protein kinase C-epsilon protects MCF-7 cells from TNF-mediated cell death by inhibiting Bax translocation. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Protein kinase C-epsilon protects MCF-7 cells from TNF-mediated cell death by inhibiting Bax translocation. Abstract Text:

Dongmei Lu,Usha Sivaprasad,Jie Huang,Eswar Shankar,Shavonda Morrow,Alakananda Basu,Dongmei Lu,Usha Sivaprasad,Jie Huang,Eswar Shankar,Shavonda Morrow,Alakananda Basu,

We have previously shown that protein kinase Cepsilon (PKCepsilon) acts as an antiapoptotic protein and protects breast cancer MCF-7 cells from tumor necrosis factor-alpha (TNF)-mediated apoptosis. In the present study, we have investigated the mechanism by which PKCepsilon inhibits TNF-induced cell death. Overexpression of wild-type PKCepsilon (WT-PKCepsilon) in MCF-7 cells decreased TNF-induced mitochondrial depolarization. Depletion of Bax by small interfering RNA (siRNA) attenuated TNF-induced cell death. Overexpression of PKCepsilon in MCF-7 cells decreased dimerization of Bax and its translocation to the mitochondria. Knockdown of PKCepsilon using siRNA induced Bax dimerization and mitochondrial translocation. PKCepsilon was coimmunoprecipitated with Bax in MCF-7 cells. These results suggest that PKCepsilon mediates its antiapoptotic effect partly by preventing activation and translocation of Bax to the mitochondria.

Protein kinase C-epsilon protects MCF-7 cells from TNF-mediated cell death by inhibiting Bax translocation. Publishing Authors By Initials

D Lu,U Sivaprasad,J Huang,E Shankar,S Morrow,A Basu,D Lu,U Sivaprasad,J Huang,E Shankar,S Morrow,A Basu,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Protein kinase C-epsilon protects MCF-7 cells from TNF-mediated cell death by inhibiting Bax translocation. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Apoptosis : an international journal on programmed

VOLUME: 12

Page Numbers: 1893-900

Journal Abbreviation: Apoptosis

ISSN: 1360-8185

DAY: 1

MONTH: Oct

YEAR: 2007

Protein kinase C-epsilon protects MCF-7 cells from TNF-mediated cell death by inhibiting Bax translocation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9712129

Protein kinase C-epsilon protects MCF-7 cells from TNF-mediated cell death by inhibiting Bax translocation. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Protein kinase C-epsilon protects MCF-7 cells from TNF-mediated cell death by inhibiting Bax translocation. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Protein kinase C-epsilon protects MCF-7 cells from TNF-mediated cell death by inhibiting Bax translocation.

AFFILIATION: Department of Molecular Biology & Immunology, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA.

Country: United States

AGENCY: United States NCI

GRANT: R01 CA71727

ACRONYM: CA

MEDLINETA: Apoptosis

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Protein kinase C-epsilon protects MCF-7 cells from TNF-mediated cell death by inhibiting Bax translocation Related Publications

• A study of the longitudinal arch of the foot.
• Airway Segmentation and Measurement in CT Images.
• An age- and gender-specific analysis of H. pylori infection.
• Antiviral and anti-inflammatory effects of rosmarinic acid in an experimental murine model of Japanese encephalitis.
• Apoptosis of human breast carcinoma cells in the presence of cis-platin and L-/D-PPMP: IV. Modulation of replication complexes and glycolipid: Glycosyltransferases.
• Cardiovascular risk with antipsychotics: case-control study or survey?
• Clinical profile and outcome of abdominal tuberculosis in Indian children.
• Cutting Edge: Stimulation of dopamine D4 receptors induce T cell quiescence by up-regulating Kruppel-like factor-2 expression through inhibition of ERK1/ERK2 phosphorylation.
• Differential colchicine-binding across eukaryotic families: the role of highly conserved Pro268beta and Ala248beta residues in animal tubulin.
• Downregulation of Bid is associated with PKCepsilon-mediated TRAIL resistance.
• Enhanced stability of cis Pro-Pro peptide bond in Pro-Pro-Phe sequence motif.
• Fractures of the patella.
• Indian biotech's bumpy road.
• Left ventricular outflow tract obstruction after mitral valve replacement.
• Macrophage protein kinase C: its role in modulating membrane microviscosity and superoxide in leishmanial infection.
• Mechanistic investigation of the oxygen-atom-transfer reactivity of dioxo-molybdenum(VI) complexes.
• Microscopes made from bamboo bring biology into focus.
• Mutagenicity of the 1-Nitropyrene-DNA Adduct N-(Deoxyguanosin-8-yl)-1-aminopyrene in Mammalian Cells.
• Neural network modeling.
• Protein kinase C-epsilon protects MCF-7 cells from TNF-mediated cell death by inhibiting Bax translocation.
• Reagentless functionalization of gold nanoparticles via a 3 + 2 Huisgen cycloaddition.
• Synthesis, molecular and electronic structure, and TDDFT and TDDFT-PCM study of the solvatochromic properties of (Me2Pipdt)Mo(CO)4 complex (Me2Pipdt = N,N'-dimethylpiperazine-2,3-dithione).
• The carbon cycle ride.
• The effect of beta-tubulin-specific antisense oligonucleotide encapsulated in different cationic liposomes on the suppression [correction of supression] of intracellular L. donovani parasites in vitro.
• The effect of spinal anaesthesia on urethral function.
• Towards optimal virtual patients: an online adaptive control approach.
• Tuberculosis of the kidney.
• Tumor necrosis factor receptor-1-induced neuronal death by TRADD contributes to the pathogenesis of Japanese encephalitis.
• Vitamin C and carbohydrate metabolism.
• Yes-Associated Protein (YAP) is a critical mediator of c-Jun-dependent apoptosis.