Protein expression and amplification of AIB1 in human urothelial carcinoma of the bladder and overexpression of AIB1 is a new independent prognostic marker of patient survival.

Protein expression and amplification of AIB1 in human urothelial carcinoma of the bladder and overexpression of AIB1 is a new independent prognostic marker of patient survival. Research Abstract Details 

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Protein expression and amplification of AIB1 in human urothelial carcinoma of the bladder and overexpression of AIB1 is a new independent prognostic marker of patient survival. Abstract Text:

Jun-Hang Luo,Dan Xie,Meng-Zhong Liu,Wei Chen,Yong-Dong Liu,Guo-Qing Wu,Hsiang-Fu Kung,Yi-Xin Zeng,Xin-Yuan Guan,Jun-Hang Luo,Dan Xie,Meng-Zhong Liu,Wei Chen,Yong-Dong Liu,Guo-Qing Wu,Hsiang-Fu Kung,Yi-Xin Zeng,Xin-Yuan Guan,

AIB1, a candidate oncogene in human breast cancer, is frequently amplified and overexpressed in several types of human cancers, but the status of AIB1 amplification and expression in urothelial carcinoma of the bladder (UC) and its clinical/prognostic significance is unclear. In our study, the methods of immunohistochemistry and fluorescence in situ hybridization were utilized to examine protein expression and amplification of AIB1 in 163 primary UCs and in 30 samples of normal bladder mucosa. Overexpression of AIB1 and amplification of AIB1 was found in 32.5 and 7.0% of UCs, respectively. In univariate survival analysis of the UC cohorts, a highly significant association of overexpression of AIB1 with shortened patient survival (mean: 45.6 months vs. 59.0 months, p < 0.001, log rank test) was demonstrated. In different subsets of UC patients, overexpression of AIB1 was also a prognostic indicator in grade 1 (p = 0.007), grade 2 (p = 0.010) and grade 3 (p = 0.015) tumor patients, and in pTa (p = 0.025), pT2-4 (p = 0.004), pN0 (p < 0.001) and pT2-4/pN0 (p = 0.040) tumor patients. Importantly, AIB1 expression (p < 0.001) together with pT and pN status (p < 0.05) provided significant independent prognostic parameters in multivariate analysis. In addition, a significant correlation (p < 0.05) of overexpression of AIB1 with an increased UC labeling index of Ki-67 (a cell proliferation marker) was observed in these UCs. Thus, these findings provide evidence that an overexpression of AIB1, as detected by immunohistochemistry, is an independent molecular marker for poor prognosis (shortened survival time) of patients with UC. (c) 2008 Wiley-Liss, Inc.

Protein expression and amplification of AIB1 in human urothelial carcinoma of the bladder and overexpression of AIB1 is a new independent prognostic marker of patient survival. Publishing Authors By Initials

JH Luo,D Xie,MZ Liu,W Chen,YD Liu,GQ Wu,HF Kung,YX Zeng,XY Guan,JH Luo,D Xie,MZ Liu,W Chen,YD Liu,GQ Wu,HF Kung,YX Zeng,XY Guan,

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Protein expression and amplification of AIB1 in human urothelial carcinoma of the bladder and overexpression of AIB1 is a new independent prognostic marker of patient survival. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of cancer. Journal internati

VOLUME: 122

Page Numbers: 2554-61

Journal Abbreviation: Int. J. Cancer

ISSN: 1097-0215

DAY: 1

MONTH: Jun

YEAR: 2008

Protein expression and amplification of AIB1 in human urothelial carcinoma of the bladder and overexpression of AIB1 is a new independent prognostic marker of patient survival. Information

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LANGUAGE: eng

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Protein expression and amplification of AIB1 in human urothelial carcinoma of the bladder and overexpression of AIB1 is a new independent prognostic marker of patient survival. Keywords Mesh Terms:

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Grant and Affiliation Information for Protein expression and amplification of AIB1 in human urothelial carcinoma of the bladder and overexpression of AIB1 is a new independent prognostic marker of patient survival.

AFFILIATION: The State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China.

Country: United States

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MEDLINETA: Int J Cancer

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