Protein C and Its inhibitor in Malignancy.

Protein C and Its inhibitor in Malignancy. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Protein C and Its inhibitor in Malignancy. Abstract Text:

Koji Suzuki,Tatsuya Hayashi,Koji Suzuki,Tatsuya Hayashi,Koji Suzuki,Tatsuya Hayashi,

Activated protein C (APC) and protein C inhibitor (PCI) are the major components of the anticoagulant protein C pathway. Recently, APC and PCI have been demonstrated to play many roles not only in the regulation of hemostasis but also in cell inflammation, proliferation, apoptosis, tumor cell migration, invasion, and metastasis. Here we summarize the role of APC and PCI in malignancy. APC increases migration of ovarian cancer cells and choriocarcinoma cells in a Transwell invasion assay in the presence of plasminogen activator inhibitor (PAI)-1; this finding suggests that APC stimulates urokinase-type plasminogen activator (uPA) by forming a complex with PAI-1 leading to activation of extracellular matrix proteases and increased invasion. It was recently reported that APC, independent of PAI-1, may increase invasion and chemotaxis of breast cancer cells by activating specific signaling pathways through endothelial protein C receptor (EPCR) and protease-activated receptor (PAR)-1. APC also increased proliferation of vascular endothelial cells and angiogenesis by EPCR-mediated activation of mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K), and endothelial nitric oxide synthase (eNOS) pathways. On the other hand, we have previously reported that both uPA and PCI are synthesized in renal proximal tubular epithelial cells (RPTECs) and that PCI expression in RPTEC-derived tumor cells is significantly decreased compared with normal RPTECs. The RPTEC-derived renal carcinoma cell line Caki-1 also showed decreased expression of PCI. PCI inhibited in vitro invasive activity of Caki-1 and breast cancer cells by its protease inhibitory activity. However, PCI was found to inhibit the growth and metastatic potential of breast cancer cells independent of its protease inhibitory activity in severe combined immunodeficient mice. PCI can also inhibit angiogenesis in vivo and in vitro assays independent of its protease inhibitory activity. Overall, these data show that APC promotes tumor cell invasion by EPCR-mediated and PAR-1-mediated protease activity and that PCI inhibits tumor cell invasion in vitro by its protease inhibitory activity and suppresses tumor cell growth, metastasis, and angiogenesis independent of its protease inhibitory activity.

Protein C and Its inhibitor in Malignancy. Publishing Authors By Initials

K Suzuki,T Hayashi,K Suzuki,T Hayashi,K Suzuki,T Hayashi,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Protein C and Its inhibitor in Malignancy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Seminars in thrombosis and hemostasis

VOLUME: 33

Page Numbers: 667-72

Journal Abbreviation: Semin. Thromb. Hemost.

ISSN: 0094-6176

DAY: 16

MONTH: Oct

YEAR: 2007

Protein C and Its inhibitor in Malignancy. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 431155

Protein C and Its inhibitor in Malignancy. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Protein C and Its inhibitor in Malignancy. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Protein C and Its inhibitor in Malignancy.

AFFILIATION: Department of Molecular Pathobiology, Mie University Graduate School of Medicine, Tsu-city, Mie, Japan.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Semin Thromb Hemost

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Protein C and Its inhibitor in Malignancy Related Publications

• Case of adult genotype C HBV carrier after acute hepatitis B, losing HBsAg and acquiring HBsAb after IFN and lamivudine treatment.
• Changes in morphology and cell number of inner cell mass of porcine blastocysts during freezing.
• Constant rate of steady-state self-antigen trafficking from skin to regional lymph nodes.
• Differential control of cell affinity required for progression and refinement of cell boundary during Drosophila leg segmentation.
• Emergence of sequence sensitivity in a hippocampal CA3-CA1 model.
• Enhancement of cellulose production by expression of sucrose synthase in acetobacter xylinum.
• Expression of Rab5a in hepatocellular carcinoma: Possible involvement in epidermal growth factor signaling.
• Heterogeneity of the developmental patterns of neurotrophin protein levels among neocortical areas of macaque monkeys.
• Hypoadiponectinemia accelerates hepatic tumor formation in a nonalcoholic steatohepatitis mouse model.
• Idiopathic thrombocytopenic purpura associated with Helicobacter pylori infection in a patient with liver cirrhosis accompanying hepatitis B.
• Immunohistochemical distribution of phosphatidylglucoside using anti-phosphatidylglucoside monoclonal antibody (DIM21).
• In situ synthesis of beta-glucan microfibrils on tobacco plasma membrane sheets.
• Injection of IL-12 gene-transduced dendritic cells into mouse liver tumor lesions activates both innate and acquired immunity.
• Isolation and Hypoglycemic Activity of Dioscorans A, B, C, D, E, and F; Glycans of Dioscorea japonica Rhizophors1.
• Isolation and Hypoglycemic Activity of Ganoderans A and B, Glycans of Ganoderma lucidum Fruit Bodies1.
• Lack of aberrations of the BMP4, BMP2, and PTX1 genes in a patient with pituitary hypoplasia, os odontoideum, renal dysplasia, and right leg anomalies.
• Late coronary thrombosis secondary to implantation of paclitaxel-eluting stent without restenosis of conventional stents.
• Loss of control over eating reflects eating disturbances and general psychopathology.
• Mineralization of matrix vesicles isolated from a human osteosarcoma cell line in culture with water-soluble chitosan-containing medium.
• Molecular phylogeny of the deep-sea Buccinum species (Gastropoda: Buccinidae) around Japan: inter- and intraspecific relationships inferred from mitochondrial 16SrRNA sequences.
• Re-evaluation of the kidney tumors and renal histopathology occurring in a 2-year rat carcinogenicity bioassay of quercetin.
• Reduced expression and functional impairment of Toll-like receptor 2 on dendritic cells in chronic hepatitis C virus infection.
• Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95-neuroligin.
• Should aged patients with chronic hepatitis C be treated with interferon and ribavirin combination therapy?
• Size and shape of charged micelles of ionic surfactants in aqueous salt solutions.
• Small hepatocellular carcinoma presenting with massive metastasis in the peritoneum, mimicking sarcomatous tumor.
• Stage- and sex-dependent expressions of Usp9x, an X-linked mouse ortholog of Drosophila Fat facets, during gonadal development and oogenesis in mice.
• Thymus and activation regulated chemokines in children with atopic dermatitis: Kyushu University Ishigaki Atopic Dermatitis Study (KIDS).
• Triple therapy of initial high-dose interferon with ribavirin and amantadine for patients with chronic hepatitis C.
• Visualization of F-actin and G-actin equilibrium using fluorescence resonance energy transfer (FRET) in cultured cells and neurons in slices.