Protein and antibody in lavage fluid of guinea pigs with Legionella pneumophila pneumonia.

Protein and antibody in lavage fluid of guinea pigs with Legionella pneumophila pneumonia. Research Abstract Details 

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Protein and antibody in lavage fluid of guinea pigs with Legionella pneumophila pneumonia. Abstract Text:

Guinea pigs were infected in an inhalation facility that limited an aerosol of L. pneumophila to the snout, as previously reported in detail (Davis et al., 1982). Individual animals were sacrificed for study either immediately after exposure, at 16 hours, at days one through seven, or at 11 days. Bronchoalveolar lavage was carried out to obtain fluid to study the following: total protein, albumin and immunoglobulin G (IgG) concentrations, and the titer of antibody to L. pneumophila. Antibody also was measured in serum obtained at the time of sacrifice. Concentrations of total protein, albumin, and IgG in lavage fluids peaked 2 days after exposure and correlated with the appearance of maximal numbers of polymorphonuclear cells in the lungs. Presumably, this increased protein resulted from exudation of serum across the alveolar-capillary membrane, which loses its integrity secondary to pneumonia. However, the ratio of IgG/albumin was elevated in animals studied 11 days after exposure even though the concentration of albumin was normal by this time. One possible explanation for this observation is that IgG was being produced in the lung. Antibody in lavage fluid was detected 7, and 11 days post-exposure, and might be important in the recovery of guinea pigs from this infection.

Protein and antibody in lavage fluid of guinea pigs with Legionella pneumophila pneumonia. Publishing Authors By Initials

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Protein and antibody in lavage fluid of guinea pigs with Legionella pneumophila pneumonia. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Zentralblatt für Bakteriologie, Mikrobiologie und

VOLUME: 255

Page Numbers: 145-9

Journal Abbreviation:

ISSN: 0174-3031

DAY: 26

MONTH: Jul

YEAR: 1983

Protein and antibody in lavage fluid of guinea pigs with Legionella pneumophila pneumonia. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8110566

Protein and antibody in lavage fluid of guinea pigs with Legionella pneumophila pneumonia. Keywords Mesh Terms:

KEYWORDS: Proteins

MESH TERMS: analysis

Chemical & Substance for Abstract: Protein and antibody in lavage fluid of guinea pigs with Legionella pneumophila pneumonia. Information

Substance Name: Proteins

Registry Number: 0

Grant and Affiliation Information for Protein and antibody in lavage fluid of guinea pigs with Legionella pneumophila pneumonia.

AFFILIATION:

Country: GERMANY, WEST

AGENCY: United States NIAID

GRANT: R01-AI15903

ACRONYM: AI

MEDLINETA: Zentralbl Bakteriol Mikrobiol

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