Protective role of Bacillus anthracis exosporium in macrophage-mediated killing by nitric oxide.

Protective role of Bacillus anthracis exosporium in macrophage-mediated killing by nitric oxide. Research Abstract Details 

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Protective role of Bacillus anthracis exosporium in macrophage-mediated killing by nitric oxide. Abstract Text:

John Weaver,Tae Jin Kang,Kimberly W Raines,Guan-Liang Cao,Stephen Hibbs,Pei Tsai,Les Baillie,Gerald M Rosen,Alan S Cross,

The ability of the endospore-forming, gram-positive bacterium Bacillus anthracis to survive in activated macrophages is key to its germination and survival. In a previous publication, we discovered that exposure of primary murine macrophages to B. anthracis endospores upregulated NOS 2 concomitant with an .NO-dependent bactericidal response. Since NOS 2 also generates O(2).(-), experiments were designed to determine whether NOS 2 formed peroxynitrite (ONOO(-)) from the reaction of .NO with O(2).(-) and if so, was ONOO(-) microbicidal toward B. anthracis. Our findings suggest that ONOO(-) was formed upon macrophage infection by B. anthracis endospores; however, ONOO(-) does not appear to exhibit microbicidal activity toward this bacterium. In contrast, the exosporium of B. anthracis, which exhibits arginase activity, protected B. anthracis from macrophage-mediated killing by decreasing .NO levels in the macrophage. Thus, the ability of B. anthracis to subvert .NO production has important implications in the control of B. anthracis-induced infection.

Protective role of Bacillus anthracis exosporium in macrophage-mediated killing by nitric oxide. Publishing Authors By Initials

J Weaver,TJ Kang,KW Raines,GL Cao,S Hibbs,P Tsai,L Baillie,GM Rosen,AS Cross,

For similar cells: spores: spores, bacterial research abstracts see: cells: spores: spores, bacterial research

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Protective role of Bacillus anthracis exosporium in macrophage-mediated killing by nitric oxide. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Infection and immunity

VOLUME: 75

Page Numbers: 3894-901

Journal Abbreviation: Infect. Immun.

ISSN: 0019-9567

DAY: 14

MONTH: 05

YEAR: 2007

Protective role of Bacillus anthracis exosporium in macrophage-mediated killing by nitric oxide. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 246127

Protective role of Bacillus anthracis exosporium in macrophage-mediated killing by nitric oxide. Keywords Mesh Terms:

KEYWORDS: Spores, Bacterial

MESH TERMS: physiology

Chemical & Substance for Abstract: Protective role of Bacillus anthracis exosporium in macrophage-mediated killing by nitric oxide. Information

Substance Name: Peroxynitrous Acid

Registry Number: 14691-52-2

Grant and Affiliation Information for Protective role of Bacillus anthracis exosporium in macrophage-mediated killing by nitric oxide.

AFFILIATION: Center for Vaccine Development, Department of Medicine, University of Maryland School of Medicine, 685 W. Baltimore Street, Baltimore, MD 21201, USA.

Country: United States

AGENCY: United States NIAID

GRANT: U54 AI 057168

ACRONYM: AI

MEDLINETA: Infect Immun

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