Protective effects of a new metalloporphyrin on paraquat-induced oxidative stress and apoptosis in N27 cells.

Protective effects of a new metalloporphyrin on paraquat-induced oxidative stress and apoptosis in N27 cells. Research Abstract Details 

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Protective effects of a new metalloporphyrin on paraquat-induced oxidative stress and apoptosis in N27 cells. Abstract Text:

Ping Chen,Ang Li,Mengjie Zhang,Meilan He,Zhen Chen,Xiaokang Wu,Chunjun Zhao,Shilong Wang,Liping Liang,Ping Chen,Ang Li,Mengjie Zhang,Meilan He,Zhen Chen,Xiaokang Wu,Chunjun Zhao,Shilong Wang,Liping Liang,

Paraquat (PQ, 1,1'-dimethyl-4,4'-bipyridinium), a widely-used herbicide, has been suggested as a potential etiologic factor for the development of Parkinson's disease. In recent years, many studies have focused on the mechanism(s) of PQ neurotoxicity. In this study, we examined the neuroprotective effect of manganese (III) meso-tetrakis (N,N'-diethylimidazolium) porphyrin (MnTDM), a superoxide dismutase/catalase mimetic, on PQ-induced oxidative stress and apoptosis in 1RB3AN27 (N27) cells, a dopaminergic neuronal cell line. The results indicated that MnTDM significantly attenuated PQ-induced loss of cell viability, glutathione depletion, and reactive oxygen species production. MnTDM also ameliorated PQ-induced morphological nuclear changes of apoptosis and increased rates of apoptosis. In addition, our data provide direct evidence that MnTDM suppressed PQ-induced caspase-3 cleavage, possibly a key event of PQ neurotoxicity. These observations suggested that oxidative stress and apoptosis are implicated in PQ-induced neurotoxicity and this toxicity could be prevented by MnTDM. These findings also proposed a novel therapeutic approach for Parkinson's disease and other disorders associated with oxidative stress.

Protective effects of a new metalloporphyrin on paraquat-induced oxidative stress and apoptosis in N27 cells. Publishing Authors By Initials

P Chen,A Li,M Zhang,M He,Z Chen,X Wu,C Zhao,S Wang,L Liang,P Chen,A Li,M Zhang,M He,Z Chen,X Wu,C Zhao,S Wang,L Liang,

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Protective effects of a new metalloporphyrin on paraquat-induced oxidative stress and apoptosis in N27 cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta biochimica et biophysica Sinica

VOLUME: 40

Page Numbers: 125-32

Journal Abbreviation: Acta Biochim. Biophys. Sin. (S

ISSN: 1745-7270

DAY: 31

MONTH: Feb

YEAR: 2008

Protective effects of a new metalloporphyrin on paraquat-induced oxidative stress and apoptosis in N27 cells. Information

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LANGUAGE: eng

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AFFILIATION: School of Life Science and Technology and 2 Department of Neurosurgery, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200092, China. liangliping@mail.tongji.edu.cn.

Country: China

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MEDLINETA: Acta Biochim Biophys Sin (Shan

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