Protective effect of non-selective and selective COX-2-inhibitors in acute immobilization stress-induced behavioral and biochemical alterations.

Protective effect of non-selective and selective COX-2-inhibitors in acute immobilization stress-induced behavioral and biochemical alterations. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Protective effect of non-selective and selective COX-2-inhibitors in acute immobilization stress-induced behavioral and biochemical alterations. Abstract Text:

Beenta Kumari,Anil Kumar,Ashish Dhir,

Acute stress has been known to produce several behavioral, neurochemical and biochemical alterations. Cyclooxygenase (COX) enzymes are involved in pathogenesis of several brain disorders including Alzheimer disease, epilepsy, depression, in addition to pain and inflammation. In the present study, we examined the role of non-selective (naproxen) and selective (rofecoxib, valdecoxib) COX-2 inhibitors against acute immobilization stress-induced behavioral alterations and oxidative damage in mice. Mice were subjected to acute immobilization stress for a period of 6 h. Naproxen (7 and 14 mg/kg, ip), rofecoxib (5 and 10 mg/kg, ip) or valdecoxib (5 and 10 mg/kg, ip) were administered 30 min before acute stress. Six-our immobilization stress significantly caused anxiety-like behavior, memory deficit and impaired motor activity as well as oxidative damage (raised lipid peroxidation, nitrite activity, depletion of reduced glutathione and catalase activity) as compared to naive animals placed on sawdust (p < 0.05). Pretreatment with naproxen (7 and 14 mg/kg, ip), rofecoxib (5 and 10 mg/kg, ip) and valdecoxib (5 and 10 mg/kg, ip) significantly improved locomotor activity, antianxiety effect, memory retention (memory deficit) and attenuated oxidative damage (lowering of raised malondialdehyde, nitrite activity, restoration of reduced glutathione and catalase activity as compared to immobilization stress group (p < 0.05). Results suggest the neuroprotective and antioxidant effect of both non-selective and selective COX-2 inhibitors.

Protective effect of non-selective and selective COX-2-inhibitors in acute immobilization stress-induced behavioral and biochemical alterations. Publishing Authors By Initials

B Kumari,A Kumar,A Dhir,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Protective effect of non-selective and selective COX-2-inhibitors in acute immobilization stress-induced behavioral and biochemical alterations. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pharmacological reports : PR

VOLUME: 59

Page Numbers: 699-707

Journal Abbreviation:

ISSN: 1734-1140

DAY: 15

MONTH: 01

YEAR: 2008

Protective effect of non-selective and selective COX-2-inhibitors in acute immobilization stress-induced behavioral and biochemical alterations. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101234999

Protective effect of non-selective and selective COX-2-inhibitors in acute immobilization stress-induced behavioral and biochemical alterations. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Protective effect of non-selective and selective COX-2-inhibitors in acute immobilization stress-induced behavioral and biochemical alterations. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Protective effect of non-selective and selective COX-2-inhibitors in acute immobilization stress-induced behavioral and biochemical alterations.

AFFILIATION: Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India. kumaruips@yahoo.com.

Country: Poland

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Pharmacol Rep

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Protective effect of non-selective and selective COX-2-inhibitors in acute immobilization stress-induced behavioral and biochemical alterations Related Publications

• Beetle injury of cornea.
• Cardiac arrest after the removal of a central venous catheter.
• Cataractogenous effect of hair dyes. (A clinical and experimental study).
• Course of the nerve fibres in the temporal half of the retina.
• Intraoperative loss of nasal jewelry: anesthetic concerns and airway management.
• On the mechanism of antidepressant-like action of berberine chloride.
• Phacomorphic glaucoma--management and visual prognosis.
• Prevalence of incidental prostate cancer in the general population: a study of healthy organ donors.
• Prostate cancer biobanking.
• Protective effect of non-selective and selective COX-2-inhibitors in acute immobilization stress-induced behavioral and biochemical alterations.
• Recent advances in paediatric cardiac anaesthesia.
• Senile macular degeneration in northern India.
• Tissue microarrays : an overview.
• Tubercular tarsitis.
• Value of fluorescein angiography in clinical ophthalmology.
• Whole genome SNP arrays as a potential diagnostic tool for the detection of characteristic chromosomal aberrations in renal epithelial tumors.
• Withania somnifera: An Indian ginseng.
• p16(ink4) immunoreactivity is a reliable marker for urothelial carcinoma in situ.