[Protective effect of ligustrazine and propofol on peri-operational liver ischemia-reperfusion injury]

[Protective effect of ligustrazine and propofol on peri-operational liver ischemia-reperfusion injury] Research Abstract Details 

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[Protective effect of ligustrazine and propofol on peri-operational liver ischemia-reperfusion injury] Abstract Text:

Wan-Tie Wang,Li-Na Lin,Jin-Ze Wu,Zhengyang Hu,Kejian Xie,Wan-Tie Wang,Li-Na Lin,Jin-Ze Wu,Zhengyang Hu,Kejian Xie,

OBJECTIVE: To explore the protective effect and mechanism of ligustrazine (LGT) and propofol (PRO) on peri-operational liver ischemia-reperfusion injury (HIRI). METHODS: Thirty-six patients scheduled for hepatic surgery were randomly divided into the control group, the LGT group, the PRO group and the LGT + PRO group, 9 patients in each group. Changes of superoxide dismutase (SOD), lipid peroxide (LPO), ratio of thromboxane B2 (TXB2) and 6-keto-prostaglandin F1alpha (6-keto-PGF1alpha), alanine aminotransferase (ALT) activity, and the ultrastructure of liver tissue were dynamically observed. RESULTS: Compared with the control group, SOD activity was significantly higher, LPO concentration, TXB2/6-keto-PGF1alpha ratio and ALT value were significantly lower (P < 0.05 and P < 0.01) in the LGT group, the PRO group and the LGT + PRO group during HIRI, with the abnormal changes of hepatic ultrastructure 25 min after reperfusion significantly alleviated in the three treated group. CONCLUSION: Combination of ligustrazine and propofol shows protective effect on liver by decreasing oxygen free radical level, reducing lipid peroxidation and adjusting TXA2/PGI2 imbalance after hepatic ischemia-reperfusion in patients undergoing hepatic cancer surgery.

[Protective effect of ligustrazine and propofol on peri-operational liver ischemia-reperfusion injury] Publishing Authors By Initials

WT Wang,LN Lin,JZ Wu,Z Hu,K Xie,WT Wang,LN Lin,JZ Wu,Z Hu,K Xie,

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[Protective effect of ligustrazine and propofol on peri-operational liver ischemia-reperfusion injury] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongx

VOLUME: 26

Page Numbers: 205-8

Journal Abbreviation: Zhongguo Zhong Xi Yi Jie He Za

ISSN: 1003-5370

DAY: 14

MONTH: Mar

YEAR: 2006

[Protective effect of ligustrazine and propofol on peri-operational liver ischemia-reperfusion injury] Information

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LANGUAGE: chi

NlmUniqueID: 9211576

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Grant and Affiliation Information for [Protective effect of ligustrazine and propofol on peri-operational liver ischemia-reperfusion injury]

AFFILIATION: Department of Pathophysiology, Wenzhou Medical College, Zhejiang. wzwwt@tom.com

Country: China

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MEDLINETA: Zhongguo Zhong Xi Yi Jie He Za

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