Protective effect of glycyrrhizin and matrine on acute vanishing bile duct syndrome induced by alpha-naphthylisothiocyanate in rats.

Protective effect of glycyrrhizin and matrine on acute vanishing bile duct syndrome induced by alpha-naphthylisothiocyanate in rats. Research Abstract Details 

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Protective effect of glycyrrhizin and matrine on acute vanishing bile duct syndrome induced by alpha-naphthylisothiocyanate in rats. Abstract Text:

Ying Zhao,Desheng Zhai,Xijing Chen,Hui He,Qin Lu,Qiaoling Yu,

Aim: To explore the effects of glycyrrhizin (GL) and matrine (MT) on acute vanishing bile duct syndromes (AVBDS) in rats. Methods: AVBDS in rats were induced by alphanaphthylisothiocyanate (ANIT), and the effects of GL and MT on AVBDS were explored and compared with dexamethasone (DEX) by serology determination, histological assessment of liver damage and bile excretion experiments. Results: The protection of DEX pre-treatment was directed toward cholangiocytes rather than hepatocytes. Rats remedially treated with DEX 3 h after ANIT were not resistant to ANIT toxicity. Notably, remedial treatment with DEX 12 h after ANIT enhanced ANIT toxicity. However, GL and MT attenuated both bile duct and hepatocyte damage induced by ANIT in the initial phase of impairment. Conclusion: The nature products (GL and MT) exhibited better protection against ANIT-induced AVBDS than DEX. In the initial phase of impairment of AVBDS, the protection of GL and MT may be due partially to modifying the metabolism and excretion of ANIT and to their anti-inflammatory effects.

Protective effect of glycyrrhizin and matrine on acute vanishing bile duct syndrome induced by alpha-naphthylisothiocyanate in rats. Publishing Authors By Initials

Y Zhao,D Zhai,X Chen,H He,Q Lu,Q Yu,

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Protective effect of glycyrrhizin and matrine on acute vanishing bile duct syndrome induced by alpha-naphthylisothiocyanate in rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Hepatology research : the official journal of the

VOLUME: 37

Page Numbers: 143-51

Journal Abbreviation: Hepatol. Res.

ISSN: 1386-6346

DAY: 15

MONTH: Feb

YEAR: 2007

Protective effect of glycyrrhizin and matrine on acute vanishing bile duct syndrome induced by alpha-naphthylisothiocyanate in rats. Information

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LANGUAGE: eng

NlmUniqueID: 9711801

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AFFILIATION: Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China.

Country: Netherlands

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MEDLINETA: Hepatol Res

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