Protective effect of Amomi semen extract on alloxan-induced pancreatic beta-cell damage.

Protective effect of Amomi semen extract on alloxan-induced pancreatic beta-cell damage. Research Abstract Details 

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Protective effect of Amomi semen extract on alloxan-induced pancreatic beta-cell damage. Abstract Text:

Ji-Hyun Lee,Jin-Woo Park,Jong-Suk Kim,Byung-Hyun Park,Hye-Won Rho,Ji-Hyun Lee,Jin-Woo Park,Jong-Suk Kim,Byung-Hyun Park,Hye-Won Rho,

The protective effect of Amomi semen extract (ASE) on alloxan-induced pancreatic beta-cell damage was investigated in HIT T-15 cells, a Syrian hamster pancreatic beta-cell line. Alloxan caused pancreatic beta-cell damage through the generation of reactive oxygen species (ROS), the elevation of cytosolic free Ca(2+), DNA fragmentation and the decrease of cellular NAD(+) and ATP levels. All these effects of alloxan were significantly prevented by pretreatment with a water-soluble extract of Amomi semen. Pretreatment with ASE in pancreatic islets isolated from mice, also significantly abolished the inhibition of glucose-stimulated insulin secretion by alloxan. The results of this study provide evidence that ASE may have a protective activity on alloxan-induced beta-cell damage, and that the protective effect is primarily due to the inhibition of ROS generation by alloxan. Copyright (c) 2007 John Wiley & Sons, Ltd.

Protective effect of Amomi semen extract on alloxan-induced pancreatic beta-cell damage. Publishing Authors By Initials

JH Lee,JW Park,JS Kim,BH Park,HW Rho,JH Lee,JW Park,JS Kim,BH Park,HW Rho,

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Protective effect of Amomi semen extract on alloxan-induced pancreatic beta-cell damage. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Phytotherapy research : PTR

VOLUME: 22

Page Numbers: 86-90

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ISSN: 0951-418X

DAY: 3

MONTH: Jan

YEAR: 2008

Protective effect of Amomi semen extract on alloxan-induced pancreatic beta-cell damage. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Protective effect of Amomi semen extract on alloxan-induced pancreatic beta-cell damage.

AFFILIATION: Department of Biochemistry, Medical School, Chonbuk National University, Jeonju, 561-756, Jeonbuk, Republic of Korea.

Country: England

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MEDLINETA: Phytother Res

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