Protective activity of the purified protein antigen of Erysipelothrix rhusiopathiae in pigs.

Protective activity of the purified protein antigen of Erysipelothrix rhusiopathiae in pigs. Research Abstract Details 

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Protective activity of the purified protein antigen of Erysipelothrix rhusiopathiae in pigs. Abstract Text:

Y Yamazaki,H Sato,H Sakakura,K Shigeto,K Nakano,H Saito,N Maehara,

We purified the protein antigen (P64), which contains 66 and 64 kDa proteins, from the alkaline extract (AE) of whole cells of Erysipelothrix rhusiopathiae strain Agata (serovar 5) to determine the protective activity of the antigen against E. rhusiopathiae infection in pigs. The serum titre of antibody against P64 rapidly increased in pigs immunized with 500 and 100 micrograms of P64 and reached maximum values at 3 weeks after the first immunization (1 week after the second immunization). However, the serum antibody titres were not increased in pigs immunized with 20 micrograms of P64 and in nonimmunized pigs. In the pigs immunized with live cell vaccine (acriflavin-fast attenuated strain Koganei 65-0.15), the serum titres of antibody against P64 also increased at 1-2 weeks after immunization. In a pig challenge test performed on immunized and nonimmunized pigs, all nonimmunized pigs showed typical clinical signs of swine erysipelas (fever, erysipeloid, arthritis), while all pigs immunized with 500 and 100 micrograms of P64 and live cell vaccine showed no clinical signs of this disease. In Western blot analysis, sera from pigs immunized with P64 and live cell vaccine strongly reacted with the 64 kDa protein. In contrast, the serum from nonimmunized pigs did not react with any proteins. From these results, it was suggested that a specific antibody against the 64 kDa protein could be increased in pigs immunized with P64 or live cell vaccine and that this anti-P64 antibody has a strong protective effect against E. rhusiopathiae infection in pigs.

Protective activity of the purified protein antigen of Erysipelothrix rhusiopathiae in pigs. Publishing Authors By Initials

Y Yamazaki,H Sato,H Sakakura,K Shigeto,K Nakano,H Saito,N Maehara,

For similar animal diseases: swine diseases research abstracts see: animal diseases: swine diseases research

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Protective activity of the purified protein antigen of Erysipelothrix rhusiopathiae in pigs. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zentralblatt für Veterinärmedizin. Reihe B. Journa

VOLUME: 46

Page Numbers: 47-55

Journal Abbreviation: Zentralblatt Veterinarmedizin

ISSN: 0514-7166

DAY: 13

MONTH: Feb

YEAR: 1999

Protective activity of the purified protein antigen of Erysipelothrix rhusiopathiae in pigs. Information

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LANGUAGE: eng

NlmUniqueID: 331325

Protective activity of the purified protein antigen of Erysipelothrix rhusiopathiae in pigs. Keywords Mesh Terms:

KEYWORDS: Swine Diseases

MESH TERMS: prevention & control

Chemical & Substance for Abstract: Protective activity of the purified protein antigen of Erysipelothrix rhusiopathiae in pigs. Information

Substance Name: Bacterial Vaccines

Registry Number: 0

Grant and Affiliation Information for Protective activity of the purified protein antigen of Erysipelothrix rhusiopathiae in pigs.

AFFILIATION: Department of Veterinary Microbiology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Aomori, Japan.

Country: GERMANY

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MEDLINETA: Zentralbl Veterinarmed B

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