Protection of mice from Shiga toxin-2 toxemia by mucosal vaccine of Shiga toxin 2B-His with Escherichia coli enterotoxin.

Protection of mice from Shiga toxin-2 toxemia by mucosal vaccine of Shiga toxin 2B-His with Escherichia coli enterotoxin. Research Abstract Details 

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Protection of mice from Shiga toxin-2 toxemia by mucosal vaccine of Shiga toxin 2B-His with Escherichia coli enterotoxin. Abstract Text:

Takao Tsuji,Takeshi Shimizu,Keiko Sasaki,Yoshiyasu Shimizu,Kentaro Tsukamoto,Hideyuki Arimitsu,Sadayuki Ochi,Satoshi Sugiyama,Koki Taniguchi,Paola Neri,Hiroshi Mori,

Escherichia coli O157:H7 produces Stx1 and Stx2 causing severe diseases. Their B subunits (StxBs) are useful for a vaccine but exhibit low immunogenicity, especially Stx2B. Nasal vaccination with StxBs plus cholera toxin induces only serum anti-Stx1B antibodies in mice. However, nasal administration of a mutant of E. coli enterotoxin and His-tagged Stx2B induced serum antibodies neutralizing Stx2 in vitro or in vivo and mucosal IgA antibodies in lungs. As His-tagged Stx2B showed five or three polymers in gel filtration chromatography, His-tagged Stx2B forms smaller tertiary structure than the native one and is effective for preventing Stx2 toxemia as a nasal vaccine.

Protection of mice from Shiga toxin-2 toxemia by mucosal vaccine of Shiga toxin 2B-His with Escherichia coli enterotoxin. Publishing Authors By Initials

T Tsuji,T Shimizu,K Sasaki,Y Shimizu,K Tsukamoto,H Arimitsu,S Ochi,S Sugiyama,K Taniguchi,P Neri,H Mori,

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Protection of mice from Shiga toxin-2 toxemia by mucosal vaccine of Shiga toxin 2B-His with Escherichia coli enterotoxin. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Vaccine

VOLUME: 26

Page Numbers: 469-76

Journal Abbreviation: Vaccine

ISSN: 0264-410X

DAY: 3

MONTH: 12

YEAR: 2007

Protection of mice from Shiga toxin-2 toxemia by mucosal vaccine of Shiga toxin 2B-His with Escherichia coli enterotoxin. Information

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LANGUAGE: eng

NlmUniqueID: 8406899

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Grant and Affiliation Information for Protection of mice from Shiga toxin-2 toxemia by mucosal vaccine of Shiga toxin 2B-His with Escherichia coli enterotoxin.

AFFILIATION: Department of Microbiology, Fujita Health University, School of Medicine, Toyoake, Aichi 470-1192, Japan.

Country: Netherlands

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MEDLINETA: Vaccine

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