Protection of cerebellar granule cells by tocopherols and tocotrienols against methylmercury toxicity.

Protection of cerebellar granule cells by tocopherols and tocotrienols against methylmercury toxicity. Research Abstract Details 

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Protection of cerebellar granule cells by tocopherols and tocotrienols against methylmercury toxicity. Abstract Text:

Mototada Shichiri,Yasukazu Takanezawa,Koji Uchida,Hiroshi Tamai,Hiroyuki Arai,Mototada Shichiri,Yasukazu Takanezawa,Koji Uchida,Hiroshi Tamai,Hiroyuki Arai,Mototada Shichiri,Yasukazu Takanezawa,Koji Uchida,Hiroshi Tamai,Hiroyuki Arai,

Excessive free radical formation has been implicated as one of the causative factors in neurotoxic damage associated with variety of metals, including methylmercury (MeHg). Although the mechanisms associated with MeHg-dependent neurotoxicity remains are unclear, it is known that MeHg leads to neurotoxicity in cerebellar granule cells (CGCs). In vitro exposure of murine CGC primary cultures to MeHg resulted in time- and concentration-dependent cell death. The present study was designed to assess the effect of fat-soluble antioxidant tocopherols and tocotrienols (unsaturated vitamin E) on MeHg-induced neurotoxicity using cultured CGCs. Significant protection from MeHg-induced neuronal cell death was observed with both tocopherols and tocotrienols. Moreover, we observed that tocotrienols are multi-fold more potent than tocopherols in protecting CGCs against MeHg neurotoxicity. At micromolar concentration, tocotrienols, but not tocopherols, showed complete protection by an antioxidant mechanism. Similarly, tocopherols and tocotrienols showed a protective effect on CGCs migration against MeHg-toxicity. These results suggested that oxidative events may contribute to MeHg toxicity in isolated cerebellar granule neurons, and that tocotrienols are potent supplements for pharmacological protection of the developing brain exposed to MeHg.

Protection of cerebellar granule cells by tocopherols and tocotrienols against methylmercury toxicity. Publishing Authors By Initials

M Shichiri,Y Takanezawa,K Uchida,H Tamai,H Arai,M Shichiri,Y Takanezawa,K Uchida,H Tamai,H Arai,M Shichiri,Y Takanezawa,K Uchida,H Tamai,H Arai,

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Protection of cerebellar granule cells by tocopherols and tocotrienols against methylmercury toxicity. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Brain research

VOLUME: 1182

Page Numbers: 106-15

Journal Abbreviation: Brain Res.

ISSN: 0006-8993

DAY: 20

MONTH: 09

YEAR: 2007

Protection of cerebellar granule cells by tocopherols and tocotrienols against methylmercury toxicity. Information

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LANGUAGE: eng

NlmUniqueID: 45503

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AFFILIATION: Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Department of Pediatrics, Osaka Medical College, 2-7 Daigakumachi, Takatsuki, Osaka 569-8686, Japan.

Country: Netherlands

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MEDLINETA: Brain Res

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