Protection against Western diet-induced obesity and hepatic steatosis in liver fatty acid-binding protein knockout mice.

Protection against Western diet-induced obesity and hepatic steatosis in liver fatty acid-binding protein knockout mice. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Protection against Western diet-induced obesity and hepatic steatosis in liver fatty acid-binding protein knockout mice. Abstract Text:

Elizabeth P Newberry,Yan Xie,Susan M Kennedy,Jianyang Luo,Nicholas O Davidson,

Liver fatty acid-binding protein (L-Fabp) regulates murine hepatic fatty acid trafficking in response to fasting. In this study, we show that L-Fabp(-/-) mice fed a high-fat Western diet for up to 18 weeks are less obese and accumulate less hepatic triglyceride than C57BL/6J controls. Paradoxically, both control and L-Fabp(-/-) mice manifested comparable glucose intolerance and insulin resistance when fed a Western diet. Protection against obesity in Western diet-fed L-Fabp(-/-) mice was not due to discernable changes in food intake, fat malabsorption, or heat production, although intestinal lipid secretion kinetics were significantly slower in both chow-fed and Western diet-fed L-Fabp(-/-) mice. By contrast, there was a significant increase in the respiratory exchange ratio in L-Fabp(-/-) mice, suggesting a shift in energy substrate use from fat to carbohydrate, findings supported by an approximately threefold increase in serum lactate. Microarray analysis revealed increased expression of genes involved in lipid synthesis (fatty acid synthase, squalene epoxidase, hydroxy-methylglutaryl coenzyme A reductase), while genes involved in glycolysis (glucokinase and glycerol kinase) were decreased in L-Fabp(-/-) mice. Fatty acid synthase expression was also increased in the skeletal muscle of L-Fabp(-/-) mice. In conclusion, L-Fabp may function as a metabolic sensor in regulating lipid homeostasis. We suggest that L-Fabp(-/-) mice are protected against Western diet-induced obesity and hepatic steatosis through a series of adaptations in both hepatic and extrahepatic energy substrate use. (HEPATOLOGY 2006;44:1191-1205.).

Protection against Western diet-induced obesity and hepatic steatosis in liver fatty acid-binding protein knockout mice. Publishing Authors By Initials

EP Newberry,Y Xie,SM Kennedy,J Luo,NO Davidson,

For similar nucleic acids, nucleotides, and nucleosides: nucleic acids: rna: rna, messenger research abstracts see: nucleic acids, nucleotides, and nucleosides: nucleic acids: rna: rna, messenger research

PUBMED ID PMID:

MEDLINE DATE:

Protection against Western diet-induced obesity and hepatic steatosis in liver fatty acid-binding protein knockout mice. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Hepatology (Baltimore, Md.)

VOLUME: 44

Page Numbers: 1191-205

Journal Abbreviation: Hepatology

ISSN: 0270-9139

DAY: 3

MONTH: Nov

YEAR: 2006

Protection against Western diet-induced obesity and hepatic steatosis in liver fatty acid-binding protein knockout mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8302946

Protection against Western diet-induced obesity and hepatic steatosis in liver fatty acid-binding protein knockout mice. Keywords Mesh Terms:

KEYWORDS: RNA, Messenger

MESH TERMS: analysis

Chemical & Substance for Abstract: Protection against Western diet-induced obesity and hepatic steatosis in liver fatty acid-binding protein knockout mice. Information

Substance Name: Fatty Acid Synthetase Complex

Registry Number: EC 6.-

Grant and Affiliation Information for Protection against Western diet-induced obesity and hepatic steatosis in liver fatty acid-binding protein knockout mice.

AFFILIATION: Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63105, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL-38180

ACRONYM: HL

MEDLINETA: Hepatology

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Protection against Western diet-induced obesity and hepatic steatosis in liver fatty acid-binding protein knockout mice Related Publications

• (Pro)Insulin processing: a historical perspective.
• Adjuvant hormonal therapy for premenopausal women with breast cancer.
• Amygdala volume and nonverbal social impairment in adolescent and adult males with autism.
• Ceramide structural features required to stimulate ABCA1-mediated cholesterol efflux to apolipoprotein A-I.
• Comparing tongue shapes from ultrasound imaging using smoothing spline analysis of variance.
• Consistent relationships between sensory properties of savory snack foods and calories influence food intake in rats.
• Course of depressive symptoms and medication adherence after acute coronary syndromes: an electronic medication monitoring study.
• Depression vulnerabilities in patients with different levels of depressive symptoms after acute coronary syndromes.
• Difference spectrophotometric assay of 1,2-diphenolic drugs in pharmaceutical formulations - I. Boric acid reagent.
• Difference spectrophotometric assay of 1,2-diphenolic drugs in pharmaceutical formulations -III. The simultaneous assay of levodopa and benserazide.
• Effects of stimulus level on the speech perception abilities of children using cochlear implants or digital hearing AIDS.
• Event-related functional magnetic resonance imaging measures of neural activity to positive social stimuli in pre- and post-treatment depression.
• Granular cell tumour of the bile duct mimicking distal cholangiocarcinoma: one case report and review of the literature.
• High regulatory gene use in sea urchin embryogenesis: Implications for bilaterian development and evolution.
• Hindgut specification and cell-adhesion functions of Sphox11/13b in the endoderm of the sea urchin embryo.
• Identification and characterization of homeobox transcription factor genes in Strongylocentrotus purpuratus, and their expression in embryonic development.
• Kava in generalized anxiety disorder: three placebo-controlled trials.
• Mechanistic possibilities in MauG-dependent tryptophan tryptophylquinone biosynthesis.
• POLARIZED ABSORPTION SPECTRA OF SINGLE CRYSTALS OF 1-METHYLTHYMINE, 9-METHYLADENINE, AND THEIR HYDROGEN-BONDED COMPLEX.
• Peripartum changes in the bovine placenta related to fetal membrane retention.
• Persistent depression affects adherence to secondary prevention behaviors after acute coronary syndromes.
• Persistent depressive symptoms lower aspirin adherence after acute coronary syndromes.
• Pharmacist staffing, technology use, and implementation of medication safety practices in rural hospitals.
• Premorbid intra-individual variability in intellectual performance and risk for schizophrenia: a population-based study.
• Protection against Western diet-induced obesity and hepatic steatosis in liver fatty acid-binding protein knockout mice.
• RNA polymerase III transcribes human microRNAs.
• Silencing estrogen receptor alpha in breast cancer cells.
• The C2H2 zinc finger genes of Strongylocentrotus purpuratus and their expression in embryonic development.
• The temperature dependence of derivative ultraviolet absorption spectra.
• What else can we do to combat stigma?