Protection against radiation-induced bone marrow and intestinal injuries by Cordyceps sinensis, a Chinese herbal medicine.

Protection against radiation-induced bone marrow and intestinal injuries by Cordyceps sinensis, a Chinese herbal medicine. Research Abstract Details 

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Protection against radiation-induced bone marrow and intestinal injuries by Cordyceps sinensis, a Chinese herbal medicine. Abstract Text:

Wei-Chung Liu,Shu-Chi Wang,Min-Lung Tsai,Meng-Chi Chen,Ya-Chen Wang,Ji-Hong Hong,William H McBride,Chi-Shiun Chiang,

Bone marrow and intestinal damage limits the efficacy of radiotherapy for cancer and can result in death if the whole body is exposed to too high a dose, as might be the case in a nuclear accident or terrorist incident. Identification of an effective nontoxic biological radioprotector is therefore a matter of some urgency. In this study, we show that an orally administered hot-water extract from a Chinese herbal medicine, Cordyceps sinensis (CS), protects mice from bone marrow and intestinal injuries after total-body irradiation (TBI). CS increased the median time to death from 13 to 20 days after 8 Gy TBI and from 9 to 18 days after 10 Gy TBI. Although CS-treated mice receiving 10 Gy TBI survived intestinal injury, most died from bone marrow failure, as shown by severe marrow hypoplasia in mice dying between 18 and 24 days. At lower TBI doses of 5.5 and 6.5 Gy, CS protected against bone marrow death, an effect that was confirmed by the finding that white blood cell counts recovered more rapidly. In vitro, CS reduced the levels of free radical species (ROS) within cells, and this is one likely mechanism for the radioprotective effects of CS, although probably not the only one.

Protection against radiation-induced bone marrow and intestinal injuries by Cordyceps sinensis, a Chinese herbal medicine. Publishing Authors By Initials

WC Liu,SC Wang,ML Tsai,MC Chen,YC Wang,JH Hong,WH McBride,CS Chiang,

For similar investigative techniques: epidemiologic methods: data collection: vital statistics: mortality: survival rate research abstracts see: investigative techniques: epidemiologic methods: data collection: vital statistics: mortality: survival rate research

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Protection against radiation-induced bone marrow and intestinal injuries by Cordyceps sinensis, a Chinese herbal medicine. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Radiation research

VOLUME: 166

Page Numbers: 900-7

Journal Abbreviation: Radiat. Res.

ISSN: 0033-7587

DAY: 3

MONTH: Dec

YEAR: 2006

Protection against radiation-induced bone marrow and intestinal injuries by Cordyceps sinensis, a Chinese herbal medicine. Information

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LANGUAGE: eng

NlmUniqueID: 401245

Protection against radiation-induced bone marrow and intestinal injuries by Cordyceps sinensis, a Chinese herbal medicine. Keywords Mesh Terms:

KEYWORDS: Survival Rate

MESH TERMS: drug effects

Chemical & Substance for Abstract: Protection against radiation-induced bone marrow and intestinal injuries by Cordyceps sinensis, a Chinese herbal medicine. Information

Substance Name: Drugs, Chinese Herbal

Registry Number: 0

Grant and Affiliation Information for Protection against radiation-induced bone marrow and intestinal injuries by Cordyceps sinensis, a Chinese herbal medicine.

AFFILIATION: Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 30013, Taiwan.

Country: United States

AGENCY: United States NIAID

GRANT: 1U19AI067769

ACRONYM: AI

MEDLINETA: Radiat Res

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